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Structural insight into activation of homoserine dehydrogenase from the archaeon Sulfolobus tokodaii via reduction

Homoserine dehydrogenase (HSD; 305 amino acid residues) catalyzes an NAD(P)-dependent reversible reaction between l-homoserine and aspartate 4-semialdehyde and is involved in the aspartate pathway. HSD from the hyperthermophilic archaeon Sulfolobus tokodaii was markedly activated (2.5-fold) by the a...

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Detalles Bibliográficos
Autores principales:	Tomonaga, Yoshihisa, Kaneko, Ryosuke, Goto, Masaru, Ohshima, Toshihisa, Yoshimune, Kazuaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668673/ https://www.ncbi.nlm.nih.gov/pubmed/29124164 http://dx.doi.org/10.1016/j.bbrep.2015.07.006

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