Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer

Deregulation and activation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian (or mechanistic) target of rapamycin (mTOR) pathway have a major role in proliferation and cell survival in breast cancer. However, as single agents, mTOR inhibitors have had modest antitumor efficacy. In this study, w...

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Detalles Bibliográficos
Autores principales: Woo, S-U, Sangai, T, Akcakanat, A, Chen, H, Wei, C, Meric-Bernstam, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668884/
https://www.ncbi.nlm.nih.gov/pubmed/28991258
http://dx.doi.org/10.1038/oncsis.2017.86

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