Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways

Transcriptional deregulation of oncogenic pathways is a hallmark of cancer and can be due to epigenetic alterations. 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification that has not been studied in pancreatic cancer. Genome-wide analysis of 5-hmC-enriched loci with hmC-seal was conducted i...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Sanchari, Pradhan, Kith, Campbell, Nathaniel, Mazdo, Jozef, Vasantkumar, Aparna, Maqbool, Shahina, Bhagat, Tushar D., Gupta, Sonal, Suzuki, Masako, Yu, Yiting, Greally, John M., Steidl, Ulrich, Bradner, James, Dawlaty, Meelad, Godley, Lucy, Maitra, Anirban, Verma, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668941/
https://www.ncbi.nlm.nih.gov/pubmed/28986391
http://dx.doi.org/10.1101/gr.222794.117

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