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Single-cell sequencing data reveal widespread recurrence and loss of mutational hits in the life histories of tumors
Intra-tumor heterogeneity poses substantial challenges for cancer treatment. A tumor's composition can be deduced by reconstructing its mutational history. Central to current approaches is the infinite sites assumption that every genomic position can only mutate once over the lifetime of a tumo...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668945/ https://www.ncbi.nlm.nih.gov/pubmed/29030470 http://dx.doi.org/10.1101/gr.220707.117 |