High-throughput single-molecule telomere characterization

We have developed a novel method that enables global subtelomere and haplotype-resolved analysis of telomere lengths at the single-molecule level. An in vitro CRISPR/Cas9 RNA-directed nickase system directs the specific labeling of human (TTAGGG)n DNA tracts in genomes that have also been barcoded u...

Descripción completa

Detalles Bibliográficos
Autores principales: McCaffrey, Jennifer, Young, Eleanor, Lassahn, Katy, Sibert, Justin, Pastor, Steven, Riethman, Harold, Xiao, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668947/
https://www.ncbi.nlm.nih.gov/pubmed/29025896
http://dx.doi.org/10.1101/gr.222422.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668947/
https://www.ncbi.nlm.nih.gov/pubmed/29025896
http://dx.doi.org/10.1101/gr.222422.117

Ejemplares similares