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High-throughput single-molecule telomere characterization

We have developed a novel method that enables global subtelomere and haplotype-resolved analysis of telomere lengths at the single-molecule level. An in vitro CRISPR/Cas9 RNA-directed nickase system directs the specific labeling of human (TTAGGG)n DNA tracts in genomes that have also been barcoded u...

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Detalles Bibliográficos
Autores principales:	McCaffrey, Jennifer, Young, Eleanor, Lassahn, Katy, Sibert, Justin, Pastor, Steven, Riethman, Harold, Xiao, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668947/ https://www.ncbi.nlm.nih.gov/pubmed/29025896 http://dx.doi.org/10.1101/gr.222422.117

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