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Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach
Titania-supported palladium, gold and bimetallic nanoparticles (second-generation nanoparticles) demonstrate promising photocatalytic properties. However, due to unusual reactivity, second-generation nanoparticles can be hazardous for living organisms. Considering the ever-growing number of new type...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669235/ https://www.ncbi.nlm.nih.gov/pubmed/29114443 http://dx.doi.org/10.3762/bjnano.8.216 |
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author | Mikolajczyk, Alicja Sizochenko, Natalia Mulkiewicz, Ewa Malankowska, Anna Nischk, Michal Jurczak, Przemyslaw Hirano, Seishiro Nowaczyk, Grzegorz Zaleska-Medynska, Adriana Leszczynski, Jerzy Gajewicz, Agnieszka Puzyn, Tomasz |
author_facet | Mikolajczyk, Alicja Sizochenko, Natalia Mulkiewicz, Ewa Malankowska, Anna Nischk, Michal Jurczak, Przemyslaw Hirano, Seishiro Nowaczyk, Grzegorz Zaleska-Medynska, Adriana Leszczynski, Jerzy Gajewicz, Agnieszka Puzyn, Tomasz |
author_sort | Mikolajczyk, Alicja |
collection | PubMed |
description | Titania-supported palladium, gold and bimetallic nanoparticles (second-generation nanoparticles) demonstrate promising photocatalytic properties. However, due to unusual reactivity, second-generation nanoparticles can be hazardous for living organisms. Considering the ever-growing number of new types of nanoparticles that can potentially contaminate the environment, a determination of their toxicity is extremely important. The main aim of presented study was to investigate the cytotoxic effect of surface modified TiO(2)-based nanoparticles, to model their quantitative nanostructure–toxicity relationships and to reveal the toxicity mechanism. In this context, toxicity tests for surface-modified TiO(2)-based nanoparticles were performed in vitro, using Gram-negative bacteria Escherichia coli and Chinese hamster ovary (CHO-K1) cells. The obtained cytotoxicity data were analyzed by means of computational methods (quantitative structure–activity relationships, QSAR approach). Based on a combined experimental and computational approach, predictive models were developed, and relationships between cytotoxicity, size, and specific surface area (Brunauer–Emmett–Teller surface, BET) of nanoparticles were discussed. |
format | Online Article Text |
id | pubmed-5669235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-56692352017-11-07 Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach Mikolajczyk, Alicja Sizochenko, Natalia Mulkiewicz, Ewa Malankowska, Anna Nischk, Michal Jurczak, Przemyslaw Hirano, Seishiro Nowaczyk, Grzegorz Zaleska-Medynska, Adriana Leszczynski, Jerzy Gajewicz, Agnieszka Puzyn, Tomasz Beilstein J Nanotechnol Full Research Paper Titania-supported palladium, gold and bimetallic nanoparticles (second-generation nanoparticles) demonstrate promising photocatalytic properties. However, due to unusual reactivity, second-generation nanoparticles can be hazardous for living organisms. Considering the ever-growing number of new types of nanoparticles that can potentially contaminate the environment, a determination of their toxicity is extremely important. The main aim of presented study was to investigate the cytotoxic effect of surface modified TiO(2)-based nanoparticles, to model their quantitative nanostructure–toxicity relationships and to reveal the toxicity mechanism. In this context, toxicity tests for surface-modified TiO(2)-based nanoparticles were performed in vitro, using Gram-negative bacteria Escherichia coli and Chinese hamster ovary (CHO-K1) cells. The obtained cytotoxicity data were analyzed by means of computational methods (quantitative structure–activity relationships, QSAR approach). Based on a combined experimental and computational approach, predictive models were developed, and relationships between cytotoxicity, size, and specific surface area (Brunauer–Emmett–Teller surface, BET) of nanoparticles were discussed. Beilstein-Institut 2017-10-17 /pmc/articles/PMC5669235/ /pubmed/29114443 http://dx.doi.org/10.3762/bjnano.8.216 Text en Copyright © 2017, Mikolajczyk et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjnano/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (https://www.beilstein-journals.org/bjnano/terms) |
spellingShingle | Full Research Paper Mikolajczyk, Alicja Sizochenko, Natalia Mulkiewicz, Ewa Malankowska, Anna Nischk, Michal Jurczak, Przemyslaw Hirano, Seishiro Nowaczyk, Grzegorz Zaleska-Medynska, Adriana Leszczynski, Jerzy Gajewicz, Agnieszka Puzyn, Tomasz Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach |
title | Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach |
title_full | Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach |
title_fullStr | Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach |
title_full_unstemmed | Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach |
title_short | Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach |
title_sort | evaluating the toxicity of tio(2)-based nanoparticles to chinese hamster ovary cells and escherichia coli: a complementary experimental and computational approach |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669235/ https://www.ncbi.nlm.nih.gov/pubmed/29114443 http://dx.doi.org/10.3762/bjnano.8.216 |
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