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Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach

Titania-supported palladium, gold and bimetallic nanoparticles (second-generation nanoparticles) demonstrate promising photocatalytic properties. However, due to unusual reactivity, second-generation nanoparticles can be hazardous for living organisms. Considering the ever-growing number of new type...

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Autores principales: Mikolajczyk, Alicja, Sizochenko, Natalia, Mulkiewicz, Ewa, Malankowska, Anna, Nischk, Michal, Jurczak, Przemyslaw, Hirano, Seishiro, Nowaczyk, Grzegorz, Zaleska-Medynska, Adriana, Leszczynski, Jerzy, Gajewicz, Agnieszka, Puzyn, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669235/
https://www.ncbi.nlm.nih.gov/pubmed/29114443
http://dx.doi.org/10.3762/bjnano.8.216
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author Mikolajczyk, Alicja
Sizochenko, Natalia
Mulkiewicz, Ewa
Malankowska, Anna
Nischk, Michal
Jurczak, Przemyslaw
Hirano, Seishiro
Nowaczyk, Grzegorz
Zaleska-Medynska, Adriana
Leszczynski, Jerzy
Gajewicz, Agnieszka
Puzyn, Tomasz
author_facet Mikolajczyk, Alicja
Sizochenko, Natalia
Mulkiewicz, Ewa
Malankowska, Anna
Nischk, Michal
Jurczak, Przemyslaw
Hirano, Seishiro
Nowaczyk, Grzegorz
Zaleska-Medynska, Adriana
Leszczynski, Jerzy
Gajewicz, Agnieszka
Puzyn, Tomasz
author_sort Mikolajczyk, Alicja
collection PubMed
description Titania-supported palladium, gold and bimetallic nanoparticles (second-generation nanoparticles) demonstrate promising photocatalytic properties. However, due to unusual reactivity, second-generation nanoparticles can be hazardous for living organisms. Considering the ever-growing number of new types of nanoparticles that can potentially contaminate the environment, a determination of their toxicity is extremely important. The main aim of presented study was to investigate the cytotoxic effect of surface modified TiO(2)-based nanoparticles, to model their quantitative nanostructure–toxicity relationships and to reveal the toxicity mechanism. In this context, toxicity tests for surface-modified TiO(2)-based nanoparticles were performed in vitro, using Gram-negative bacteria Escherichia coli and Chinese hamster ovary (CHO-K1) cells. The obtained cytotoxicity data were analyzed by means of computational methods (quantitative structure–activity relationships, QSAR approach). Based on a combined experimental and computational approach, predictive models were developed, and relationships between cytotoxicity, size, and specific surface area (Brunauer–Emmett–Teller surface, BET) of nanoparticles were discussed.
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spelling pubmed-56692352017-11-07 Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach Mikolajczyk, Alicja Sizochenko, Natalia Mulkiewicz, Ewa Malankowska, Anna Nischk, Michal Jurczak, Przemyslaw Hirano, Seishiro Nowaczyk, Grzegorz Zaleska-Medynska, Adriana Leszczynski, Jerzy Gajewicz, Agnieszka Puzyn, Tomasz Beilstein J Nanotechnol Full Research Paper Titania-supported palladium, gold and bimetallic nanoparticles (second-generation nanoparticles) demonstrate promising photocatalytic properties. However, due to unusual reactivity, second-generation nanoparticles can be hazardous for living organisms. Considering the ever-growing number of new types of nanoparticles that can potentially contaminate the environment, a determination of their toxicity is extremely important. The main aim of presented study was to investigate the cytotoxic effect of surface modified TiO(2)-based nanoparticles, to model their quantitative nanostructure–toxicity relationships and to reveal the toxicity mechanism. In this context, toxicity tests for surface-modified TiO(2)-based nanoparticles were performed in vitro, using Gram-negative bacteria Escherichia coli and Chinese hamster ovary (CHO-K1) cells. The obtained cytotoxicity data were analyzed by means of computational methods (quantitative structure–activity relationships, QSAR approach). Based on a combined experimental and computational approach, predictive models were developed, and relationships between cytotoxicity, size, and specific surface area (Brunauer–Emmett–Teller surface, BET) of nanoparticles were discussed. Beilstein-Institut 2017-10-17 /pmc/articles/PMC5669235/ /pubmed/29114443 http://dx.doi.org/10.3762/bjnano.8.216 Text en Copyright © 2017, Mikolajczyk et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjnano/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (https://www.beilstein-journals.org/bjnano/terms)
spellingShingle Full Research Paper
Mikolajczyk, Alicja
Sizochenko, Natalia
Mulkiewicz, Ewa
Malankowska, Anna
Nischk, Michal
Jurczak, Przemyslaw
Hirano, Seishiro
Nowaczyk, Grzegorz
Zaleska-Medynska, Adriana
Leszczynski, Jerzy
Gajewicz, Agnieszka
Puzyn, Tomasz
Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach
title Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach
title_full Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach
title_fullStr Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach
title_full_unstemmed Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach
title_short Evaluating the toxicity of TiO(2)-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach
title_sort evaluating the toxicity of tio(2)-based nanoparticles to chinese hamster ovary cells and escherichia coli: a complementary experimental and computational approach
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669235/
https://www.ncbi.nlm.nih.gov/pubmed/29114443
http://dx.doi.org/10.3762/bjnano.8.216
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