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ERK inhibition sensitizes CZ415-induced anti-osteosarcoma activity in vitro and in vivo

mTOR is a valuable oncotarget for osteosarcoma. The anti-osteosarcoma activity by a novel mTOR kinase inhibitor, CZ415, was evaluated. We demonstrated that CZ415 potently inhibited survival and proliferation of known osteosarcoma cell lines (U2OS, MG-63 and SaOs2), and primary human osteosarcoma cel...

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Detalles Bibliográficos
Autores principales:	Yin, Gang, Fan, Jin, Zhou, Wei, Ding, Qingfeng, Zhang, Jun, Wu, Xuan, Tang, Pengyu, Zhou, Hao, Wan, Bowen, Yin, Guoyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669867/ https://www.ncbi.nlm.nih.gov/pubmed/29137241 http://dx.doi.org/10.18632/oncotarget.18303

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