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Antitumor efficacy of triple monoclonal antibody inhibition of epidermal growth factor receptor (EGFR) with MM151 in EGFR-dependent and in cetuximab-resistant human colorectal cancer cells

PURPOSE: We investigated the effect of triple monoclonal antibody inhibition of EGFR to overcome acquired resistance to first generation of anti-EGFR inhibitors. EXPERIMENTAL DESIGN: MM151 is a mixture of three different monoclonal IgG1 antibodies directed toward three different, non-overlapping, ep...

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Detalles Bibliográficos
Autores principales:	Napolitano, Stefania, Martini, Giulia, Martinelli, Erika, Della Corte, Carminia Maria, Morgillo, Floriana, Belli, Valentina, Cardone, Claudia, Matrone, Nunzia, Ciardiello, Fortunato, Troiani, Teresa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669927/ https://www.ncbi.nlm.nih.gov/pubmed/29137301 http://dx.doi.org/10.18632/oncotarget.19797

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