The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of Alzheimer disease suggesting a correlation between ocular and brain pathologies

Recently a range of ocular manifestations such as retinal and lens amyloid-beta accumulation and retinal nerve fiber layer loss have been proposed as potential biomarkers in Alzheimer disease (AD). The TgCRND8 mouse model of AD exhibits age-dependent amyloid β (Aβ) oligomers accumulation and cogniti...

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Detalles Bibliográficos
Autores principales: Buccarello, Lucia, Sclip, Alessandra, Sacchi, Matteo, Castaldo, Anna Maria, Bertani, Ilaria, ReCecconi, Andrea, Maestroni, Silvia, Zerbini, Gianpaolo, Nucci, Paolo, Borsello, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669948/
https://www.ncbi.nlm.nih.gov/pubmed/29137322
http://dx.doi.org/10.18632/oncotarget.19886

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