NVP-BKM120 inhibits colon cancer growth via FoxO3a-dependent PUMA induction

NVP-BKM120, a potent and highly selective PI3K inhibitor, is currently being investigated in phase I/II clinical trials. The mechanisms of action of NVP-BKM120 in colon cancer cells are unclear. In the present study, we investigated how NVP-BKM120 suppresses colon cancer cells growth and potentiates...

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Detalles Bibliográficos
Autores principales: Yang, Shida, Li, Xin, Guan, Wenchang, Qian, Mingqin, Yao, Zhicheng, Yin, Xiaoxue, Zhao, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669949/
https://www.ncbi.nlm.nih.gov/pubmed/29137323
http://dx.doi.org/10.18632/oncotarget.20943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669949/
https://www.ncbi.nlm.nih.gov/pubmed/29137323
http://dx.doi.org/10.18632/oncotarget.20943

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