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NVP-BKM120 inhibits colon cancer growth via FoxO3a-dependent PUMA induction

NVP-BKM120, a potent and highly selective PI3K inhibitor, is currently being investigated in phase I/II clinical trials. The mechanisms of action of NVP-BKM120 in colon cancer cells are unclear. In the present study, we investigated how NVP-BKM120 suppresses colon cancer cells growth and potentiates...

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Detalles Bibliográficos
Autores principales:	Yang, Shida, Li, Xin, Guan, Wenchang, Qian, Mingqin, Yao, Zhicheng, Yin, Xiaoxue, Zhao, Hongmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669949/ https://www.ncbi.nlm.nih.gov/pubmed/29137323 http://dx.doi.org/10.18632/oncotarget.20943

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