Cargando…

Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis

Some studies investigated the association between highly up-regulated in liver cancer (HULC) and the overall survival (OS) of cancer. However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis to determine the association between HULC and the OS of cancer. A co...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yong, Liu, Yi-Hong, Chen, Xian, Zhu, Yan-Juan, Zhang, Hai-Bo, Li, Yan, Bai, Jian-Ping, Liu, Li-Rong, Qu, Yan-Chun, Qu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669964/
https://www.ncbi.nlm.nih.gov/pubmed/29137338
http://dx.doi.org/10.18632/oncotarget.18452
_version_ 1783275940679254016
author Li, Yong
Liu, Yi-Hong
Chen, Xian
Zhu, Yan-Juan
Zhang, Hai-Bo
Li, Yan
Bai, Jian-Ping
Liu, Li-Rong
Qu, Yan-Chun
Qu, Xin
author_facet Li, Yong
Liu, Yi-Hong
Chen, Xian
Zhu, Yan-Juan
Zhang, Hai-Bo
Li, Yan
Bai, Jian-Ping
Liu, Li-Rong
Qu, Yan-Chun
Qu, Xin
author_sort Li, Yong
collection PubMed
description Some studies investigated the association between highly up-regulated in liver cancer (HULC) and the overall survival (OS) of cancer. However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis to determine the association between HULC and the OS of cancer. A comprehensive online search was conducted on Online electronic databases (PubMed, EMBASE, and Wanfang database) from the earliest date to Aug 30, 2016. The strength of the association was calculated with the HRs and respective 95% CIs. The expression of HULC was significantly associated with OS of cancers (HR = 2.12; 95% CI 1.61 – 2.79; P<0.00001). In the subgroup analysis by ethnicity, the expression of HULC was significantly associated with OS in Chinese patients (HR = 2.04; 95% CI 1.55 – 2.70; P<0.00001). In the subgroup analysis by cancer type, HULC was associated with OS in osteosarcoma patients (HR = 3.36; 95% CI 1.02 – 11.07; P = 0.05) and in gastric cancer patients (HR = 2.17; 95% CI 1.08 – 4.38; P = 0.03). We performed the sensitivity analysis to assess the stability of the meta-analysis. A significant association was found in studies with adjustment (HR = 2.01; 95% CI 1.35 – 2.99; P= 0.0006). In conclusion, this meta-analysis suggested that high expression of HULC was significantly associated with OS of cancer.
format Online
Article
Text
id pubmed-5669964
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-56699642017-11-09 Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis Li, Yong Liu, Yi-Hong Chen, Xian Zhu, Yan-Juan Zhang, Hai-Bo Li, Yan Bai, Jian-Ping Liu, Li-Rong Qu, Yan-Chun Qu, Xin Oncotarget Meta-Analysis Some studies investigated the association between highly up-regulated in liver cancer (HULC) and the overall survival (OS) of cancer. However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis to determine the association between HULC and the OS of cancer. A comprehensive online search was conducted on Online electronic databases (PubMed, EMBASE, and Wanfang database) from the earliest date to Aug 30, 2016. The strength of the association was calculated with the HRs and respective 95% CIs. The expression of HULC was significantly associated with OS of cancers (HR = 2.12; 95% CI 1.61 – 2.79; P<0.00001). In the subgroup analysis by ethnicity, the expression of HULC was significantly associated with OS in Chinese patients (HR = 2.04; 95% CI 1.55 – 2.70; P<0.00001). In the subgroup analysis by cancer type, HULC was associated with OS in osteosarcoma patients (HR = 3.36; 95% CI 1.02 – 11.07; P = 0.05) and in gastric cancer patients (HR = 2.17; 95% CI 1.08 – 4.38; P = 0.03). We performed the sensitivity analysis to assess the stability of the meta-analysis. A significant association was found in studies with adjustment (HR = 2.01; 95% CI 1.35 – 2.99; P= 0.0006). In conclusion, this meta-analysis suggested that high expression of HULC was significantly associated with OS of cancer. Impact Journals LLC 2017-06-13 /pmc/articles/PMC5669964/ /pubmed/29137338 http://dx.doi.org/10.18632/oncotarget.18452 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Li, Yong
Liu, Yi-Hong
Chen, Xian
Zhu, Yan-Juan
Zhang, Hai-Bo
Li, Yan
Bai, Jian-Ping
Liu, Li-Rong
Qu, Yan-Chun
Qu, Xin
Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis
title Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis
title_full Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis
title_fullStr Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis
title_full_unstemmed Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis
title_short Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis
title_sort effect of long non-coding rna highly up-regulated in liver cancer (hulc) on the prognosis of cancer: a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669964/
https://www.ncbi.nlm.nih.gov/pubmed/29137338
http://dx.doi.org/10.18632/oncotarget.18452
work_keys_str_mv AT liyong effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis
AT liuyihong effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis
AT chenxian effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis
AT zhuyanjuan effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis
AT zhanghaibo effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis
AT liyan effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis
AT baijianping effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis
AT liulirong effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis
AT quyanchun effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis
AT quxin effectoflongnoncodingrnahighlyupregulatedinlivercancerhulcontheprognosisofcancerametaanalysis