Cargando…

Reverse phase protein array (RPPA) combined with computational analysis to unravel relevant prognostic factors in non- small cell lung cancer (NSCLC): a pilot study

In this work high throughput technology and computational analysis were used to study two stage IV lung adenocarcinoma patients treated with standard chemotherapy with markedly different survival (128 months vs 6 months, respectively) and whose tumor samples exhibit a dissimilar protein activation p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ludovini, Vienna, Chiari, Rita, Tomassoni, Lorenzo, Antonini, Chiara, Baldelli, Elisa, Baglivo, Sara, Siggillino, Annamaria, Tofanetti, Francesca Romana, Bellezza, Guido, Hodge, K. Alex, Petricoin, Emanuel, Pierobon, Mariaelena, Crinò, Lucio, Bianconi, Fortunato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669974/ https://www.ncbi.nlm.nih.gov/pubmed/29137348 http://dx.doi.org/10.18632/oncotarget.18480

Ejemplares similares

Higher TLR7 Gene Expression Predicts Poor Clinical Outcome in Advanced NSCLC Patients Treated with Immunotherapy
por: Baglivo, Sara, et al.
Publicado: (2021)

Heterogeneous Off-Target Effects of Ultra-Low Dose Dimethyl Sulfoxide (DMSO) on Targetable Signaling Events in Lung Cancer In Vitro Models
por: Baldelli, Elisa, et al.
Publicado: (2021)

Detection of EGFR Mutations in Plasma Cell-Free Tumor DNA of TKI-Treated Advanced-NSCLC Patients by Three Methodologies: Scorpion-ARMS, PNAClamp, and Digital PCR
por: Siggillino, Annamaria, et al.
Publicado: (2020)

High PD-L1/IDO-2 and PD-L2/IDO-1 Co-Expression Levels Are Associated with Worse Overall Survival in Resected Non-Small Cell Lung Cancer Patients
por: Ludovini, Vienna, et al.
Publicado: (2021)

Wild-Type KRAS Allele Effects on Druggable Targets in KRAS Mutant Lung Adenocarcinomas
por: Baldelli, Elisa, et al.
Publicado: (2021)

Erratum to: ‘Conditional robustness analysis for fragility discovery and target identification in biochemical networks and in cancer systems biology’
por: Bianconi, Fortunato, et al.
Publicado: (2016)

Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors
por: Baldelli, Elisa, et al.
Publicado: (2015)

Gene identification for risk of relapse in stage I lung adenocarcinoma patients: a combined methodology of gene expression profiling and computational gene network analysis
por: Ludovini, Vienna, et al.
Publicado: (2016)

Dyskerin and TERC expression may condition survival in lung cancer patients
por: Penzo, Marianna, et al.
Publicado: (2015)

Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer
por: Mandarano, Martina, et al.
Publicado: (2021)

Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
por: Baldelli, Elisa, et al.
Publicado: (2022)

Conditional robustness analysis for fragility discovery and target identification in biochemical networks and in cancer systems biology
por: Bianconi, Fortunato, et al.
Publicado: (2015)

Sensitivity to Immune Checkpoint Blockade in Advanced Non-Small Cell Lung Cancer Patients with EGFR Exon 20 Insertion Mutations
por: Metro, Giulio, et al.
Publicado: (2021)

Prevalence and Spectrum of BRCA Germline Variants in Central Italian High Risk or Familial Breast/Ovarian Cancer Patients: A Monocentric Study
por: Foglietta, Jennifer, et al.
Publicado: (2020)

RET Rearrangement as a Predictor of Unresponsiveness to Immunotherapy in Non-Small Cell Lung Cancer: Report of Two Cases with Review of the Literature
por: Baglivo, Sara, et al.
Publicado: (2020)

Inflamed Tumor Phenotype as Predictor of Long-Term Response to Pembrolizumab in an EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC) Patient with Acquired Resistance to Afatinib: a Case Report and Review of the Literature
por: Baglivo, Sara, et al.
Publicado: (2022)

CRA toolbox: software package for conditional robustness analysis of cancer systems biology models in MATLAB
por: Bianconi, Fortunato, et al.
Publicado: (2019)

Application of conditional robust calibration to ordinary differential equations models in computational systems biology: a comparison of two sampling strategies
por: Bianconi, Fortunato, et al.
Publicado: (2020)

Enteric-type adenocarcinoma of the lung harbouring a novel KRAS Q22K mutation with concomitant KRAS polysomy: a case report
por: Metro, Giulio, et al.
Publicado: (2015)

PD-L1 quantification across tumor types using the reverse phase protein microarray: implications for precision medicine
por: Baldelli, Elisa, et al.
Publicado: (2021)

INSL4 as prognostic marker for proliferation and invasiveness in Non-Small-Cell Lung Cancer
por: Scopetti, Damiano, et al.
Publicado: (2021)

Osimertinib in patients with advanced epidermal growth factor receptor T790M mutation-positive non-small cell lung cancer: rationale, evidence and place in therapy
por: Ricciuti, Biagio, et al.
Publicado: (2017)

Mathematical Modeling and Robustness Analysis to Unravel COVID-19 Transmission Dynamics: The Italy Case †
por: Antonini, Chiara, et al.
Publicado: (2020)

Genome-wide expression of the residual lung reacting to experimental Pneumonectomy
por: Napolioni, Valerio, et al.
Publicado: (2021)

Prognostic Role of Circulating miRNAs in Early-Stage Non-Small Cell Lung Cancer
por: Ulivi, Paola, et al.
Publicado: (2019)

Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition
por: Koplev, Simon, et al.
Publicado: (2018)

RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data
por: Shehwana, Huma, et al.
Publicado: (2022)

Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy
por: Ludovini, Vienna, et al.
Publicado: (2017)

Concomitant TP53 Mutation Confers Worse Prognosis in EGFR-Mutated Non-Small Cell Lung Cancer Patients Treated with TKIs
por: Canale, Matteo, et al.
Publicado: (2020)

Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis
por: Le Roux, Özgün, et al.
Publicado: (2022)

Prognosis of ALK-rearranged non-small-cell lung cancer patients carrying TP53 mutations
por: Canale, Matteo, et al.
Publicado: (2022)

The impact of ultraviolet- and infrared-based laser microdissection technology on phosphoprotein detection in the laser microdissection-reverse phase protein array workflow
por: Hunt, Allison L., et al.
Publicado: (2020)

Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy
por: Torresano, Laura, et al.
Publicado: (2022)

Protein profiling by reverse phase protein array (RPPA) in classical hairy cell leukemia (HCL) and HCL‐variant
por: Hoff, Fieke W., et al.
Publicado: (2022)

Kinase-driven metabolic signalling as a predictor of response to carboplatin–paclitaxel adjuvant treatment in advanced ovarian cancers
por: Sereni, Maria Isabella, et al.
Publicado: (2017)

A Modeling Study on Vaccination and Spread of SARS-CoV-2 Variants in Italy
por: Antonini, Chiara, et al.
Publicado: (2021)

Robustness analysis for quantitative assessment of vaccination effects and SARS-CoV-2 lineages in Italy
por: Antonini, Chiara, et al.
Publicado: (2022)

Topological integration of RPPA proteomic data with multi-omics data for survival prediction in breast cancer via pathway activity inference
por: Kim, Tae Rim, et al.
Publicado: (2019)

AKT/mTOR signaling modulates resistance to endocrine therapy and CDK4/6 inhibition in metastatic breast cancers
por: Abu-Khalaf, Maysa M., et al.
Publicado: (2023)

CYP17, GSTP1, PON1 and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case-control study
por: Antognelli, Cinzia, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ir7k8apm7jeh5d07cvoc73l34o