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The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength

NADPH-cytochrome P450 reductase (CPR) is a redox partner of microsomal cytochromes P450 and is a prototype of the diflavin reductase family. CPR contains 3 distinct functional domains: a FMN-binding domain (acceptor reduction), a linker (hinge), and a connecting/FAD domain (NADPH oxidation). It has...

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Detalles Bibliográficos
Autores principales:	Campelo, Diana, Lautier, Thomas, Urban, Philippe, Esteves, Francisco, Bozonnet, Sophie, Truan, Gilles, Kranendonk, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670117/ https://www.ncbi.nlm.nih.gov/pubmed/29163152 http://dx.doi.org/10.3389/fphar.2017.00755

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