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L290P/V mutations increase ERK3’s cytoplasmic localization and migration/invasion-promoting capability in cancer cells
Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional M...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670241/ https://www.ncbi.nlm.nih.gov/pubmed/29101390 http://dx.doi.org/10.1038/s41598-017-15135-9 |