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Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease
Introduction: Variants in long non-coding RNAs (lncRNAs) have been implicated as potential biomarkers in prediction of complex disorders such as coronary artery disease (CAD). Studies considering the impact of the SENCR antisense lncRNAs on CAD have not established yet in Iranian population. This st...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670340/ https://www.ncbi.nlm.nih.gov/pubmed/29118951 http://dx.doi.org/10.15171/jcvtr.2017.29 |
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author | Shahmoradi, Nahid Nasiri, Mahboobeh Kamfiroozi, Hajar Kheiry, Mohammad Ali |
author_facet | Shahmoradi, Nahid Nasiri, Mahboobeh Kamfiroozi, Hajar Kheiry, Mohammad Ali |
author_sort | Shahmoradi, Nahid |
collection | PubMed |
description | Introduction: Variants in long non-coding RNAs (lncRNAs) have been implicated as potential biomarkers in prediction of complex disorders such as coronary artery disease (CAD). Studies considering the impact of the SENCR antisense lncRNAs on CAD have not established yet in Iranian population. This study aimed to investigate the association between SENCR rs555172 polymorphism and CAD in south Iranian population. Methods: Amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was performed to determine the allele and the genotype distribution of SENCR lncRNA polymorphism in 150 patients with CAD compared with 149 healthy controls through this hospital-based case-control study. Results: The frequency of AA, AG, and GG genotypes in cases were 32.7%, 44.7%, and 22.6%, and in controls were 26.8%, 49%, and 24.2%, respectively. Association was not found with any of the genotypes in comparison of cases and controls. The allelic frequencies did not differ between cases and controls. Cross-tabulating the population based on the gender, the frequency of the GG genotype was significantly higher among women of the case group compared to men. The difference was not seen in the control group between two sexes. Conclusion: The results suggested that the SENCR gene polymorphism did not confer susceptibility to CAD. |
format | Online Article Text |
id | pubmed-5670340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-56703402017-11-08 Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease Shahmoradi, Nahid Nasiri, Mahboobeh Kamfiroozi, Hajar Kheiry, Mohammad Ali J Cardiovasc Thorac Res Original Article Introduction: Variants in long non-coding RNAs (lncRNAs) have been implicated as potential biomarkers in prediction of complex disorders such as coronary artery disease (CAD). Studies considering the impact of the SENCR antisense lncRNAs on CAD have not established yet in Iranian population. This study aimed to investigate the association between SENCR rs555172 polymorphism and CAD in south Iranian population. Methods: Amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was performed to determine the allele and the genotype distribution of SENCR lncRNA polymorphism in 150 patients with CAD compared with 149 healthy controls through this hospital-based case-control study. Results: The frequency of AA, AG, and GG genotypes in cases were 32.7%, 44.7%, and 22.6%, and in controls were 26.8%, 49%, and 24.2%, respectively. Association was not found with any of the genotypes in comparison of cases and controls. The allelic frequencies did not differ between cases and controls. Cross-tabulating the population based on the gender, the frequency of the GG genotype was significantly higher among women of the case group compared to men. The difference was not seen in the control group between two sexes. Conclusion: The results suggested that the SENCR gene polymorphism did not confer susceptibility to CAD. Tabriz University of Medical Sciences 2017 2017-09-30 /pmc/articles/PMC5670340/ /pubmed/29118951 http://dx.doi.org/10.15171/jcvtr.2017.29 Text en © 2017 The Author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Shahmoradi, Nahid Nasiri, Mahboobeh Kamfiroozi, Hajar Kheiry, Mohammad Ali Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title | Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_full | Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_fullStr | Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_full_unstemmed | Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_short | Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_sort | association of the rs555172 polymorphism in sencr long non-coding rna and atherosclerotic coronary artery disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670340/ https://www.ncbi.nlm.nih.gov/pubmed/29118951 http://dx.doi.org/10.15171/jcvtr.2017.29 |
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