A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies

Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosom...

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Detalles Bibliográficos
Autores principales: Cheng, Lin, Wu, Shuying, Zhang, Kun, Qing, Yun’an, Xu, Tianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670635/
https://www.ncbi.nlm.nih.gov/pubmed/29100532
http://dx.doi.org/10.1186/s13048-017-0368-6
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author Cheng, Lin
Wu, Shuying
Zhang, Kun
Qing, Yun’an
Xu, Tianmin
author_facet Cheng, Lin
Wu, Shuying
Zhang, Kun
Qing, Yun’an
Xu, Tianmin
author_sort Cheng, Lin
collection PubMed
description Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the extracellular matrix component through the shuttling of cargo, such as proteins, lipids, RNAs, double-stranded DNAs, non-transcribed RNAs, and microRNAs. This phenomenon has been indicated in both tumourigenesis and drug resistance. In this review, we introduce new methods of exosome extraction, focusing on the emerging role of exosomes in ovarian cancer, and discuss their potential clinical applications.
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spelling pubmed-56706352017-11-15 A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies Cheng, Lin Wu, Shuying Zhang, Kun Qing, Yun’an Xu, Tianmin J Ovarian Res Review Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the extracellular matrix component through the shuttling of cargo, such as proteins, lipids, RNAs, double-stranded DNAs, non-transcribed RNAs, and microRNAs. This phenomenon has been indicated in both tumourigenesis and drug resistance. In this review, we introduce new methods of exosome extraction, focusing on the emerging role of exosomes in ovarian cancer, and discuss their potential clinical applications. BioMed Central 2017-11-03 /pmc/articles/PMC5670635/ /pubmed/29100532 http://dx.doi.org/10.1186/s13048-017-0368-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Cheng, Lin
Wu, Shuying
Zhang, Kun
Qing, Yun’an
Xu, Tianmin
A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies
title A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies
title_full A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies
title_fullStr A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies
title_full_unstemmed A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies
title_short A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies
title_sort comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670635/
https://www.ncbi.nlm.nih.gov/pubmed/29100532
http://dx.doi.org/10.1186/s13048-017-0368-6
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