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Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?

OBJECTIVE: Our previous genome-wide association study (GWAS) identified that the ABO rs633862 variant in chromosome 9q34.2 was associated with the risk of epithelial ovarian cancer (EOC) in Chinese Han women. The aim of the present study was to evaluate its prognostic effect on EOC. METHODS: A total...

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Autores principales: Jiang, Rong, Xu, Yuan, Wang, Pan, Cheng, Xi, Shi, Tingyan, Zang, Rongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671115/
https://www.ncbi.nlm.nih.gov/pubmed/29109911
http://dx.doi.org/10.7717/peerj.3946
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author Jiang, Rong
Xu, Yuan
Wang, Pan
Cheng, Xi
Shi, Tingyan
Zang, Rongyu
author_facet Jiang, Rong
Xu, Yuan
Wang, Pan
Cheng, Xi
Shi, Tingyan
Zang, Rongyu
author_sort Jiang, Rong
collection PubMed
description OBJECTIVE: Our previous genome-wide association study (GWAS) identified that the ABO rs633862 variant in chromosome 9q34.2 was associated with the risk of epithelial ovarian cancer (EOC) in Chinese Han women. The aim of the present study was to evaluate its prognostic effect on EOC. METHODS: A total of 669 EOC patients were enrolled for the genotyping of rs633862 variant in 9q34.2. We used Kaplan–Meier survival curves, univariate and multivariate Cox proportional hazard models to evaluate the association of rs633862 with overall survival (OS) in EOC patients. RESULTS: We found that rs633862 variant AG/GG genotypes were significantly associated with a longer OS by using univariate Cox proportional hazards regression analysis, compared with the rs633862 AA genotype (HR = 0.69, 95% CI [0.49–0.98], p = 0.035), albeit with a boardline significance in the multivariate analysis. Similar findings were observed in the subgroup of high-grade serous ovarian carcinoma. Further expression quantitative trait loci (eQTL) analysis indicated that the rs633862 AA genotype was associated with an increased level of ABO mRNA expression (p = 1.8 × 10(−11)). CONCLUSIONS: Supplementary to the previous GWAS, our study provides additional evidence on the prognostic value of the 9q34.2 rs633862 variant in EOC patients, and this variant may function by regulating the ABO mRNA expression.
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spelling pubmed-56711152017-11-06 Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer? Jiang, Rong Xu, Yuan Wang, Pan Cheng, Xi Shi, Tingyan Zang, Rongyu PeerJ Oncology OBJECTIVE: Our previous genome-wide association study (GWAS) identified that the ABO rs633862 variant in chromosome 9q34.2 was associated with the risk of epithelial ovarian cancer (EOC) in Chinese Han women. The aim of the present study was to evaluate its prognostic effect on EOC. METHODS: A total of 669 EOC patients were enrolled for the genotyping of rs633862 variant in 9q34.2. We used Kaplan–Meier survival curves, univariate and multivariate Cox proportional hazard models to evaluate the association of rs633862 with overall survival (OS) in EOC patients. RESULTS: We found that rs633862 variant AG/GG genotypes were significantly associated with a longer OS by using univariate Cox proportional hazards regression analysis, compared with the rs633862 AA genotype (HR = 0.69, 95% CI [0.49–0.98], p = 0.035), albeit with a boardline significance in the multivariate analysis. Similar findings were observed in the subgroup of high-grade serous ovarian carcinoma. Further expression quantitative trait loci (eQTL) analysis indicated that the rs633862 AA genotype was associated with an increased level of ABO mRNA expression (p = 1.8 × 10(−11)). CONCLUSIONS: Supplementary to the previous GWAS, our study provides additional evidence on the prognostic value of the 9q34.2 rs633862 variant in EOC patients, and this variant may function by regulating the ABO mRNA expression. PeerJ Inc. 2017-11-01 /pmc/articles/PMC5671115/ /pubmed/29109911 http://dx.doi.org/10.7717/peerj.3946 Text en ©2017 Jiang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Oncology
Jiang, Rong
Xu, Yuan
Wang, Pan
Cheng, Xi
Shi, Tingyan
Zang, Rongyu
Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?
title Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?
title_full Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?
title_fullStr Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?
title_full_unstemmed Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?
title_short Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?
title_sort can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671115/
https://www.ncbi.nlm.nih.gov/pubmed/29109911
http://dx.doi.org/10.7717/peerj.3946
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