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Intratumor and Intertumor Heterogeneity in Melanoma
Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features. The incidence rate escalates. A high number of clones harboring various mutations contribute to an exceptional level of intratumor heterogeneity of melanoma. It also refers to metastases which may originate fro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671412/ https://www.ncbi.nlm.nih.gov/pubmed/29078205 http://dx.doi.org/10.1016/j.tranon.2017.09.007 |
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author | Grzywa, Tomasz M. Paskal, Wiktor Włodarski, Paweł K. |
author_facet | Grzywa, Tomasz M. Paskal, Wiktor Włodarski, Paweł K. |
author_sort | Grzywa, Tomasz M. |
collection | PubMed |
description | Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features. The incidence rate escalates. A high number of clones harboring various mutations contribute to an exceptional level of intratumor heterogeneity of melanoma. It also refers to metastases which may originate from different subclones of primary lesion. Such component of the neoplasm biology is termed intertumor and intratumor heterogeneity. These levels of tumor heterogeneity hinder accurate diagnosis and effective treatment. The increasing number of research on the topic reflects the need for understanding limitation or failure of contemporary therapies. Majority of analyses concentrate on mutations in cancer-related genes. Novel high-throughput techniques reveal even higher degree of variations within a lesion. Consolidation of theories and researches indicates new routes for treatment options such as targets for immunotherapy. The demand for personalized approach in melanoma treatment requires extensive knowledge on intratumor and intertumor heterogeneity on the level of genome, transcriptome/proteome, and epigenome. Thus, achievements in exploration of melanoma variety are described in details. Particularly, the issue of tumor heterogeneity or homogeneity given BRAF mutations is discussed. |
format | Online Article Text |
id | pubmed-5671412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-56714122017-11-13 Intratumor and Intertumor Heterogeneity in Melanoma Grzywa, Tomasz M. Paskal, Wiktor Włodarski, Paweł K. Transl Oncol Review article Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features. The incidence rate escalates. A high number of clones harboring various mutations contribute to an exceptional level of intratumor heterogeneity of melanoma. It also refers to metastases which may originate from different subclones of primary lesion. Such component of the neoplasm biology is termed intertumor and intratumor heterogeneity. These levels of tumor heterogeneity hinder accurate diagnosis and effective treatment. The increasing number of research on the topic reflects the need for understanding limitation or failure of contemporary therapies. Majority of analyses concentrate on mutations in cancer-related genes. Novel high-throughput techniques reveal even higher degree of variations within a lesion. Consolidation of theories and researches indicates new routes for treatment options such as targets for immunotherapy. The demand for personalized approach in melanoma treatment requires extensive knowledge on intratumor and intertumor heterogeneity on the level of genome, transcriptome/proteome, and epigenome. Thus, achievements in exploration of melanoma variety are described in details. Particularly, the issue of tumor heterogeneity or homogeneity given BRAF mutations is discussed. Neoplasia Press 2017-10-24 /pmc/articles/PMC5671412/ /pubmed/29078205 http://dx.doi.org/10.1016/j.tranon.2017.09.007 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review article Grzywa, Tomasz M. Paskal, Wiktor Włodarski, Paweł K. Intratumor and Intertumor Heterogeneity in Melanoma |
title | Intratumor and Intertumor Heterogeneity in Melanoma |
title_full | Intratumor and Intertumor Heterogeneity in Melanoma |
title_fullStr | Intratumor and Intertumor Heterogeneity in Melanoma |
title_full_unstemmed | Intratumor and Intertumor Heterogeneity in Melanoma |
title_short | Intratumor and Intertumor Heterogeneity in Melanoma |
title_sort | intratumor and intertumor heterogeneity in melanoma |
topic | Review article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671412/ https://www.ncbi.nlm.nih.gov/pubmed/29078205 http://dx.doi.org/10.1016/j.tranon.2017.09.007 |
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