Fluorinated Adenosine A(2A) Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics

Antagonism of the adenosine A(2A) receptor on T cells blocks the hypoxia-adenosinergic pathway to promote tumor rejection. Using an in vivo immunoassay based on the Concanavalin A mouse model, a series of A(2A) antagonists were studied and identified preladenant as a potent lead compound for develop...

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Detalles Bibliográficos
Autores principales: Yuan, Gengyang, Jankins, Tanner C., Patrick, Christopher G., Philbrook, Phaethon, Sears, Olivia, Hatfield, Stephen, Sitkovsky, Michail, Vasdev, Neil, Liang, Steven H., Ondrechen, Mary Jo, Pollastri, Michael P., Jones, Graham B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671725/
https://www.ncbi.nlm.nih.gov/pubmed/29201461
http://dx.doi.org/10.1155/2017/4852537

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