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Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows

BACKGROUND: A validated scale is needed for objective and reproducible comparisons of infraorbital hollows (i.e., tear troughs) before and after treatment in practice and clinical studies. OBJECTIVE: To describe the development and validation of the 5-point photonumeric Allergan Infraorbital Hollows...

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Autores principales: Donofrio, Lisa, Carruthers, Jean, Hardas, Bhushan, Murphy, Diane K., Jones, Derek, Sykes, Jonathan M., Carruthers, Alastair, Creutz, Lela, Marx, Ann, Dill, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671793/
https://www.ncbi.nlm.nih.gov/pubmed/27661748
http://dx.doi.org/10.1097/DSS.0000000000000856
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author Donofrio, Lisa
Carruthers, Jean
Hardas, Bhushan
Murphy, Diane K.
Jones, Derek
Sykes, Jonathan M.
Carruthers, Alastair
Creutz, Lela
Marx, Ann
Dill, Sara
author_facet Donofrio, Lisa
Carruthers, Jean
Hardas, Bhushan
Murphy, Diane K.
Jones, Derek
Sykes, Jonathan M.
Carruthers, Alastair
Creutz, Lela
Marx, Ann
Dill, Sara
author_sort Donofrio, Lisa
collection PubMed
description BACKGROUND: A validated scale is needed for objective and reproducible comparisons of infraorbital hollows (i.e., tear troughs) before and after treatment in practice and clinical studies. OBJECTIVE: To describe the development and validation of the 5-point photonumeric Allergan Infraorbital Hollows Scale. METHODS: The scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 297) completed during 2 sessions occurring 3 weeks apart. RESULTS: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 0.90 [0.79–1.02] for clinically different image pairs and 0.33 [0.19–0.46] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was substantial (mean weighted kappa = 0.79). Interrater agreement was substantial during the second rating session (0.70, primary end point). CONCLUSION: The Allergan Infraorbital Hollows Scale is a validated and reliable scale for physician rating severity of hollowing in the infraorbital area.
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spelling pubmed-56717932017-11-22 Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows Donofrio, Lisa Carruthers, Jean Hardas, Bhushan Murphy, Diane K. Jones, Derek Sykes, Jonathan M. Carruthers, Alastair Creutz, Lela Marx, Ann Dill, Sara Dermatol Surg Original Article BACKGROUND: A validated scale is needed for objective and reproducible comparisons of infraorbital hollows (i.e., tear troughs) before and after treatment in practice and clinical studies. OBJECTIVE: To describe the development and validation of the 5-point photonumeric Allergan Infraorbital Hollows Scale. METHODS: The scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 297) completed during 2 sessions occurring 3 weeks apart. RESULTS: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 0.90 [0.79–1.02] for clinically different image pairs and 0.33 [0.19–0.46] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was substantial (mean weighted kappa = 0.79). Interrater agreement was substantial during the second rating session (0.70, primary end point). CONCLUSION: The Allergan Infraorbital Hollows Scale is a validated and reliable scale for physician rating severity of hollowing in the infraorbital area. Lippincott Williams & Wilkins 2016-10 2016-09-26 /pmc/articles/PMC5671793/ /pubmed/27661748 http://dx.doi.org/10.1097/DSS.0000000000000856 Text en © 2016 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
spellingShingle Original Article
Donofrio, Lisa
Carruthers, Jean
Hardas, Bhushan
Murphy, Diane K.
Jones, Derek
Sykes, Jonathan M.
Carruthers, Alastair
Creutz, Lela
Marx, Ann
Dill, Sara
Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows
title Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows
title_full Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows
title_fullStr Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows
title_full_unstemmed Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows
title_short Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows
title_sort development and validation of a photonumeric scale for evaluation of infraorbital hollows
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671793/
https://www.ncbi.nlm.nih.gov/pubmed/27661748
http://dx.doi.org/10.1097/DSS.0000000000000856
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