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Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy

BACKGROUND AND STUDY AIMS: The approach to small bowel preparation before capsule endoscopy (CE) is still suboptimal. PATIENTS AND METHODS: One hundred eighty patients were randomly allocated to 3 groups. Patients in Group A took 250 mL 20% mannitol and 1 L 0.9% saline orally at 05:00 hours on the d...

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Autores principales: Chen, Hong-bin, Lian-xiang, Peng, Yue, Huang, Chun, Huang, Shu-ping, Xiao, Rong-pang, Lin, Xiao-zong, Wang, Xiao-lin, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671836/
https://www.ncbi.nlm.nih.gov/pubmed/29069003
http://dx.doi.org/10.1097/MD.0000000000008322
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author Chen, Hong-bin
Lian-xiang, Peng
Yue, Huang
Chun, Huang
Shu-ping, Xiao
Rong-pang, Lin
Xiao-zong, Wang
Xiao-lin, Li
author_facet Chen, Hong-bin
Lian-xiang, Peng
Yue, Huang
Chun, Huang
Shu-ping, Xiao
Rong-pang, Lin
Xiao-zong, Wang
Xiao-lin, Li
author_sort Chen, Hong-bin
collection PubMed
description BACKGROUND AND STUDY AIMS: The approach to small bowel preparation before capsule endoscopy (CE) is still suboptimal. PATIENTS AND METHODS: One hundred eighty patients were randomly allocated to 3 groups. Patients in Group A took 250 mL 20% mannitol and 1 L 0.9% saline orally at 05:00 hours on the day of the procedure. In Group B the same preparation was taken at 20:00 on the day before, and at 05:00 on the day of CE; in addition, 20 mL oral simethicone was taken 30 minutes before CE. Group C was treated identically to Group B, except that the patients fasted for 3 days and took 3 g senna orally 3 times daily before CE. The length of bowel containing green luminal contents was assessed by ImageJ software and bowel cleanliness was evaluated by computed assessment of the cleansing score. RESULTS: Cleansing of the whole small bowel and the distal small bowel were significantly different between the 3 groups (χ(2) = 22.470, P = .000; χ(2) = 17.029, P = .000, respectively). There were also significant differences between the 3 groups in the length of small bowel and specifically the length of the distal small bowel containing green luminal contents (χ(2) = 12.390, P = .000, χ(2) = 15.141, P = .000, respectively), but not with regard to the proximal small bowel (χ(2) = 0.678, P = .509). CONCLUSIONS: Three days fasting and oral senna, combined with 20% mannitol and simethicone, before CE, can reduce the effects of bile on the small bowel and improve small bowel cleansing, especially in the distal small intestine.
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spelling pubmed-56718362017-11-22 Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy Chen, Hong-bin Lian-xiang, Peng Yue, Huang Chun, Huang Shu-ping, Xiao Rong-pang, Lin Xiao-zong, Wang Xiao-lin, Li Medicine (Baltimore) 4500 BACKGROUND AND STUDY AIMS: The approach to small bowel preparation before capsule endoscopy (CE) is still suboptimal. PATIENTS AND METHODS: One hundred eighty patients were randomly allocated to 3 groups. Patients in Group A took 250 mL 20% mannitol and 1 L 0.9% saline orally at 05:00 hours on the day of the procedure. In Group B the same preparation was taken at 20:00 on the day before, and at 05:00 on the day of CE; in addition, 20 mL oral simethicone was taken 30 minutes before CE. Group C was treated identically to Group B, except that the patients fasted for 3 days and took 3 g senna orally 3 times daily before CE. The length of bowel containing green luminal contents was assessed by ImageJ software and bowel cleanliness was evaluated by computed assessment of the cleansing score. RESULTS: Cleansing of the whole small bowel and the distal small bowel were significantly different between the 3 groups (χ(2) = 22.470, P = .000; χ(2) = 17.029, P = .000, respectively). There were also significant differences between the 3 groups in the length of small bowel and specifically the length of the distal small bowel containing green luminal contents (χ(2) = 12.390, P = .000, χ(2) = 15.141, P = .000, respectively), but not with regard to the proximal small bowel (χ(2) = 0.678, P = .509). CONCLUSIONS: Three days fasting and oral senna, combined with 20% mannitol and simethicone, before CE, can reduce the effects of bile on the small bowel and improve small bowel cleansing, especially in the distal small intestine. Wolters Kluwer Health 2017-10-27 /pmc/articles/PMC5671836/ /pubmed/29069003 http://dx.doi.org/10.1097/MD.0000000000008322 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0
spellingShingle 4500
Chen, Hong-bin
Lian-xiang, Peng
Yue, Huang
Chun, Huang
Shu-ping, Xiao
Rong-pang, Lin
Xiao-zong, Wang
Xiao-lin, Li
Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy
title Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy
title_full Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy
title_fullStr Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy
title_full_unstemmed Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy
title_short Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy
title_sort randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671836/
https://www.ncbi.nlm.nih.gov/pubmed/29069003
http://dx.doi.org/10.1097/MD.0000000000008322
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