Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers

Abnormal expression of activating/inhibitory receptors leads to natural killer (NK) cells dysfunction in tumor. Here we show that programmed cell death protein 1 (PD-1), a well-known immune checkpoint of T cells, is highly expressed on peripheral and tumor-infiltrating NK cells from patients with di...

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Detalles Bibliográficos
Autores principales: Liu, Y, Cheng, Y, Xu, Y, Wang, Z, Du, X, Li, C, Peng, J, Gao, L, Liang, X, Ma, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671935/
https://www.ncbi.nlm.nih.gov/pubmed/28692048
http://dx.doi.org/10.1038/onc.2017.209

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