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Carboxyl-Terminal Residues N478 and V479 Required for the Cytolytic Activity of Listeriolysin O Play a Critical Role in Listeria monocytogenes Pathogenicity

Listeria monocytogenes is a facultative intracellular pathogen that secretes the cytolysin listeriolysin O (LLO), which enables the bacteria to cross the phagosomal membrane. L. monocytogenes regulates LLO activity in the phagosome and minimizes its activity in the host cytosol. Mutants that fail to...

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Detalles Bibliográficos
Autores principales:	Cheng, Changyong, Jiang, Li, Ma, Tiantian, Wang, Hang, Han, Xiao, Sun, Jing, Yang, Yongchun, Chen, Zhongwei, Yu, Huifei, Hang, Yi, Liu, Fengdan, Wang, Bosen, Fang, Weihuan, Huang, Huarong, Fang, Chun, Cai, Chang, Freitag, Nancy, Song, Houhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671954/ https://www.ncbi.nlm.nih.gov/pubmed/29163512 http://dx.doi.org/10.3389/fimmu.2017.01439

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