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Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility

Male infertility affects men worldwide. Oxidative stress (OS), characterized by an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, is one of the major causes of male infertility. OS causes damage at the molecular level, which impairs lipids, proteins, and DNA. The cyc...

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Detalles Bibliográficos
Autores principales: Agarwal, Ashok, Bui, Albert Danh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671957/
https://www.ncbi.nlm.nih.gov/pubmed/29124237
http://dx.doi.org/10.4111/icu.2017.58.6.385
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author Agarwal, Ashok
Bui, Albert Danh
author_facet Agarwal, Ashok
Bui, Albert Danh
author_sort Agarwal, Ashok
collection PubMed
description Male infertility affects men worldwide. Oxidative stress (OS), characterized by an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, is one of the major causes of male infertility. OS causes damage at the molecular level, which impairs lipids, proteins, and DNA. The cyclic cascade of redox reactions weakens sperm function which leads to poor semen parameters and eventual sterility. There is a need for advanced diagnostic tests that can quickly and accurately detect OS. Most commonly used assays can only measure single constituents of OS. However, the MiOXSYS System introduces a new strategy to detect OS by measuring the oxidation-reduction potential (ORP)--a direct evaluation of the redox balance between ROS and antioxidants. The MiOXSYS System has shown promise as a diagnostic tool in the evaluation of male infertility. This review explores the concept of ORP, details the principle of the MiOXSYS System, and summarizes the findings in clinical studies that support ORP measurement in semen.
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spelling pubmed-56719572017-11-09 Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility Agarwal, Ashok Bui, Albert Danh Investig Clin Urol Review Article Male infertility affects men worldwide. Oxidative stress (OS), characterized by an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, is one of the major causes of male infertility. OS causes damage at the molecular level, which impairs lipids, proteins, and DNA. The cyclic cascade of redox reactions weakens sperm function which leads to poor semen parameters and eventual sterility. There is a need for advanced diagnostic tests that can quickly and accurately detect OS. Most commonly used assays can only measure single constituents of OS. However, the MiOXSYS System introduces a new strategy to detect OS by measuring the oxidation-reduction potential (ORP)--a direct evaluation of the redox balance between ROS and antioxidants. The MiOXSYS System has shown promise as a diagnostic tool in the evaluation of male infertility. This review explores the concept of ORP, details the principle of the MiOXSYS System, and summarizes the findings in clinical studies that support ORP measurement in semen. The Korean Urological Association 2017-11 2017-11-02 /pmc/articles/PMC5671957/ /pubmed/29124237 http://dx.doi.org/10.4111/icu.2017.58.6.385 Text en © The Korean Urological Association, 2017 http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Agarwal, Ashok
Bui, Albert Danh
Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility
title Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility
title_full Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility
title_fullStr Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility
title_full_unstemmed Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility
title_short Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility
title_sort oxidation-reduction potential as a new marker for oxidative stress: correlation to male infertility
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671957/
https://www.ncbi.nlm.nih.gov/pubmed/29124237
http://dx.doi.org/10.4111/icu.2017.58.6.385
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