Epistatic interactions between mutations of TACI (TNFRSF13B) and TCF3 result in a severe primary immunodeficiency disorder and systemic lupus erythematosus

Common variable immunodeficiency disorders (CVID) are a group of primary immunodeficiencies where monogenetic causes account for only a fraction of cases. On this evidence, CVID is potentially polygenic and epistatic although there are, as yet, no examples to support this hypothesis. We have identif...

Descripción completa

Detalles Bibliográficos
Autores principales: Ameratunga, Rohan, Koopmans, Wikke, Woon, See-Tarn, Leung, Euphemia, Lehnert, Klaus, Slade, Charlotte A, Tempany, Jessica C, Enders, Anselm, Steele, Richard, Browett, Peter, Hodgkin, Philip D, Bryant, Vanessa L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671988/
https://www.ncbi.nlm.nih.gov/pubmed/29114388
http://dx.doi.org/10.1038/cti.2017.41

Ejemplares similares

Ejemplares similares