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Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer

Lung cancer is one of the most common malignant tumors harmful to human health. Cytokeratin (CK) is highly conserved and differentiated related to the proliferation and differentiation of epithelial cells. The aim of the study was to explore expressions of CK20 and CK7 and corresponding prognostic v...

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Autores principales: Luo, Hai-Tao, Liang, Cai-Xia, Luo, Rong-Cheng, Gu, Wei-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672087/
https://www.ncbi.nlm.nih.gov/pubmed/28827446
http://dx.doi.org/10.1042/BSR20171086
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author Luo, Hai-Tao
Liang, Cai-Xia
Luo, Rong-Cheng
Gu, Wei-Guang
author_facet Luo, Hai-Tao
Liang, Cai-Xia
Luo, Rong-Cheng
Gu, Wei-Guang
author_sort Luo, Hai-Tao
collection PubMed
description Lung cancer is one of the most common malignant tumors harmful to human health. Cytokeratin (CK) is highly conserved and differentiated related to the proliferation and differentiation of epithelial cells. The aim of the study was to explore expressions of CK20 and CK7 and corresponding prognostic values in patients with lung cancer. Our study included 258 cases of patients confirmed with lung cancer. Expressions of CK20 and CK7 mRNA and protein were detected using real-time quantitative PCR (qRT-PCR) and Western blot, respectively, followed by the performance of immunohistochemistry staining. Associations of CK20 and CK7 with the clinical parameters and prognosis of lung cancer patients were further analyzed. There were obvious differences regarding the positive expression of CK20 in different T stage, lymph node metastasis, invasion, size, and clinical stage subgroups; besides, significant differences in the positive expression of CK7 were also observed in subgroups of different sex, age, lymph node metastasis, invasion, and differentiation. Furthermore, effects of age, smoking, T stage, lymph node metastasis and invasion, size, and CK7 expressions were significant on the survival of patients (all P<0.05). Multivariate analysis revealed that lymph node metastasis, T stage, and CK7 expression were independent risk factors for poor prognosis of involved patients (all P<0.05), while age, smoking, and invasion had no marked relation to the survival time of patients with lung cancer (all P>0.05). Positive CK20 and CK7 expressions are detected in patients with lung cancer; positive expression of CK7 associated with pathological features of lymph node metastasis and T stage may be independent clinical parameters for poor prognosis of patients with lung cancer.
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spelling pubmed-56720872017-11-07 Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer Luo, Hai-Tao Liang, Cai-Xia Luo, Rong-Cheng Gu, Wei-Guang Biosci Rep Research Articles Lung cancer is one of the most common malignant tumors harmful to human health. Cytokeratin (CK) is highly conserved and differentiated related to the proliferation and differentiation of epithelial cells. The aim of the study was to explore expressions of CK20 and CK7 and corresponding prognostic values in patients with lung cancer. Our study included 258 cases of patients confirmed with lung cancer. Expressions of CK20 and CK7 mRNA and protein were detected using real-time quantitative PCR (qRT-PCR) and Western blot, respectively, followed by the performance of immunohistochemistry staining. Associations of CK20 and CK7 with the clinical parameters and prognosis of lung cancer patients were further analyzed. There were obvious differences regarding the positive expression of CK20 in different T stage, lymph node metastasis, invasion, size, and clinical stage subgroups; besides, significant differences in the positive expression of CK7 were also observed in subgroups of different sex, age, lymph node metastasis, invasion, and differentiation. Furthermore, effects of age, smoking, T stage, lymph node metastasis and invasion, size, and CK7 expressions were significant on the survival of patients (all P<0.05). Multivariate analysis revealed that lymph node metastasis, T stage, and CK7 expression were independent risk factors for poor prognosis of involved patients (all P<0.05), while age, smoking, and invasion had no marked relation to the survival time of patients with lung cancer (all P>0.05). Positive CK20 and CK7 expressions are detected in patients with lung cancer; positive expression of CK7 associated with pathological features of lymph node metastasis and T stage may be independent clinical parameters for poor prognosis of patients with lung cancer. Portland Press Ltd. 2017-11-06 /pmc/articles/PMC5672087/ /pubmed/28827446 http://dx.doi.org/10.1042/BSR20171086 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Luo, Hai-Tao
Liang, Cai-Xia
Luo, Rong-Cheng
Gu, Wei-Guang
Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer
title Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer
title_full Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer
title_fullStr Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer
title_full_unstemmed Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer
title_short Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer
title_sort identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672087/
https://www.ncbi.nlm.nih.gov/pubmed/28827446
http://dx.doi.org/10.1042/BSR20171086
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