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Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors

Valosin-containing protein (VCP), together with several partner proteins, extracts ubiquitinated client proteins from E3 ligase complex and facilitates their degradation through ubiquitin–proteasome system. Therefore, it plays an important role in regulating protein quality control and various cellu...

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Detalles Bibliográficos
Autores principales:	Bastola, Prabhakar, Wang, Feng, Schaich, Matthew A, Gan, Taiping, Freudenthal, Bret D, Chou, Tsui-Fen, Chien, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672561/ https://www.ncbi.nlm.nih.gov/pubmed/29367883 http://dx.doi.org/10.1038/cddiscovery.2017.65

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