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Molecular design of upconversion nanoparticles for gene delivery

Due to their large anti-Stokes shifts, sharp emission spectra and long excited-state lifetimes, upconversion nanoparticles (UCNPs) have attracted an increasing amount of research interests, and have shown great potential for enhancing the practical utility of gene therapy, whose versatility has been...

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Detalles Bibliográficos
Autores principales: Lai, Wing-Fu, Rogach, Andrey L., Wong, Wing-Tak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672820/
https://www.ncbi.nlm.nih.gov/pubmed/29163885
http://dx.doi.org/10.1039/c7sc02956j
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author Lai, Wing-Fu
Rogach, Andrey L.
Wong, Wing-Tak
author_facet Lai, Wing-Fu
Rogach, Andrey L.
Wong, Wing-Tak
author_sort Lai, Wing-Fu
collection PubMed
description Due to their large anti-Stokes shifts, sharp emission spectra and long excited-state lifetimes, upconversion nanoparticles (UCNPs) have attracted an increasing amount of research interests, and have shown great potential for enhancing the practical utility of gene therapy, whose versatility has been limited by existing gene delivery technologies that are basically mono-functional in nature. Despite this, up to now in-depth analysis of the development of UCNPs for gene delivery has been scant in the literature, even though there has been an upsurge of reviews on the chemistry of UCNPs and their applications in bioimaging and drug delivery. To fill this gap, this review aims to present the latest advances in the development and applications of UCNPs as gene carriers. Prior to describing the prominent works published in the field, a critical view on the properties, chemistry and molecular design of UCNPs for gene delivery is provided. With a synopsis of the recent advances in UCNP-mediated gene delivery, challenges and opportunities could be illuminated for clinical translation of works in this nascent field of research.
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spelling pubmed-56728202017-11-21 Molecular design of upconversion nanoparticles for gene delivery Lai, Wing-Fu Rogach, Andrey L. Wong, Wing-Tak Chem Sci Chemistry Due to their large anti-Stokes shifts, sharp emission spectra and long excited-state lifetimes, upconversion nanoparticles (UCNPs) have attracted an increasing amount of research interests, and have shown great potential for enhancing the practical utility of gene therapy, whose versatility has been limited by existing gene delivery technologies that are basically mono-functional in nature. Despite this, up to now in-depth analysis of the development of UCNPs for gene delivery has been scant in the literature, even though there has been an upsurge of reviews on the chemistry of UCNPs and their applications in bioimaging and drug delivery. To fill this gap, this review aims to present the latest advances in the development and applications of UCNPs as gene carriers. Prior to describing the prominent works published in the field, a critical view on the properties, chemistry and molecular design of UCNPs for gene delivery is provided. With a synopsis of the recent advances in UCNP-mediated gene delivery, challenges and opportunities could be illuminated for clinical translation of works in this nascent field of research. Royal Society of Chemistry 2017-11-01 2017-08-29 /pmc/articles/PMC5672820/ /pubmed/29163885 http://dx.doi.org/10.1039/c7sc02956j Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Lai, Wing-Fu
Rogach, Andrey L.
Wong, Wing-Tak
Molecular design of upconversion nanoparticles for gene delivery
title Molecular design of upconversion nanoparticles for gene delivery
title_full Molecular design of upconversion nanoparticles for gene delivery
title_fullStr Molecular design of upconversion nanoparticles for gene delivery
title_full_unstemmed Molecular design of upconversion nanoparticles for gene delivery
title_short Molecular design of upconversion nanoparticles for gene delivery
title_sort molecular design of upconversion nanoparticles for gene delivery
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672820/
https://www.ncbi.nlm.nih.gov/pubmed/29163885
http://dx.doi.org/10.1039/c7sc02956j
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