A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers

A systematic review was conducted to categorize the types of cancerous tissues that express orexin receptors and also to examine the effect of in vitro administration of orexin A or B to corresponding cell samples. Comprehensive literature analyses of primary experimental studies were performed. The...

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Detalles Bibliográficos
Autores principales: Graybill, Nicole L, Weissig, Volkmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Systematic Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673000/
https://www.ncbi.nlm.nih.gov/pubmed/29147564
http://dx.doi.org/10.1177/2050312117735774
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author Graybill, Nicole L
Weissig, Volkmar
author_facet Graybill, Nicole L
Weissig, Volkmar
author_sort Graybill, Nicole L
collection PubMed
description A systematic review was conducted to categorize the types of cancerous tissues that express orexin receptors and also to examine the effect of in vitro administration of orexin A or B to corresponding cell samples. Comprehensive literature analyses of primary experimental studies were performed. The results of the review included an increased frequency of orexin receptor expression in many colon and prostate cancer tissues and an upward trend of pro-apoptotic activity in these aggressive cell types.
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spelling pubmed-56730002017-11-16 A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers Graybill, Nicole L Weissig, Volkmar SAGE Open Med Systematic Review A systematic review was conducted to categorize the types of cancerous tissues that express orexin receptors and also to examine the effect of in vitro administration of orexin A or B to corresponding cell samples. Comprehensive literature analyses of primary experimental studies were performed. The results of the review included an increased frequency of orexin receptor expression in many colon and prostate cancer tissues and an upward trend of pro-apoptotic activity in these aggressive cell types. SAGE Publications 2017-11-03 /pmc/articles/PMC5673000/ /pubmed/29147564 http://dx.doi.org/10.1177/2050312117735774 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Systematic Review
Graybill, Nicole L
Weissig, Volkmar
A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers
title A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers
title_full A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers
title_fullStr A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers
title_full_unstemmed A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers
title_short A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers
title_sort review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673000/
https://www.ncbi.nlm.nih.gov/pubmed/29147564
http://dx.doi.org/10.1177/2050312117735774
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