Cargando…

Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a major malignancy in the liver and has emerged as one of the main cancers in the world with a high mortality rate. However, the molecular mechanisms of HCC are still poorly understood. Long noncoding RNAs (lncRNAs) have recently come to the forefront as functional...

Descripción completa

Detalles Bibliográficos
Autores principales: Mehra, Mrigaya, Chauhan, Ranjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673005/
https://www.ncbi.nlm.nih.gov/pubmed/29147078
http://dx.doi.org/10.1177/1179299X17737301
_version_ 1783276532214530048
author Mehra, Mrigaya
Chauhan, Ranjit
author_facet Mehra, Mrigaya
Chauhan, Ranjit
author_sort Mehra, Mrigaya
collection PubMed
description Hepatocellular carcinoma (HCC) is a major malignancy in the liver and has emerged as one of the main cancers in the world with a high mortality rate. However, the molecular mechanisms of HCC are still poorly understood. Long noncoding RNAs (lncRNAs) have recently come to the forefront as functional non–protein-coding RNAs that are involved in a variety of cellular processes ranging from maintaining the structural integrity of chromosomes to gene expression regulation in a spatiotemporal manner. Many recent studies have reported the involvement of lncRNAs in HCC which has led to a better understanding of the underlying molecular mechanisms operating in HCC. Long noncoding RNAs have been shown to regulate development and progression of HCC, and thus, lncRNAs have both diagnostic and therapeutic potentials. In this review, we present an overview of the lncRNAs involved in different stages of HCC and their potential in clinical applications which have been studied so far.
format Online
Article
Text
id pubmed-5673005
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-56730052017-11-16 Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma Mehra, Mrigaya Chauhan, Ranjit Biomark Cancer Review Hepatocellular carcinoma (HCC) is a major malignancy in the liver and has emerged as one of the main cancers in the world with a high mortality rate. However, the molecular mechanisms of HCC are still poorly understood. Long noncoding RNAs (lncRNAs) have recently come to the forefront as functional non–protein-coding RNAs that are involved in a variety of cellular processes ranging from maintaining the structural integrity of chromosomes to gene expression regulation in a spatiotemporal manner. Many recent studies have reported the involvement of lncRNAs in HCC which has led to a better understanding of the underlying molecular mechanisms operating in HCC. Long noncoding RNAs have been shown to regulate development and progression of HCC, and thus, lncRNAs have both diagnostic and therapeutic potentials. In this review, we present an overview of the lncRNAs involved in different stages of HCC and their potential in clinical applications which have been studied so far. SAGE Publications 2017-11-02 /pmc/articles/PMC5673005/ /pubmed/29147078 http://dx.doi.org/10.1177/1179299X17737301 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Mehra, Mrigaya
Chauhan, Ranjit
Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma
title Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma
title_full Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma
title_fullStr Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma
title_full_unstemmed Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma
title_short Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma
title_sort long noncoding rnas as a key player in hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673005/
https://www.ncbi.nlm.nih.gov/pubmed/29147078
http://dx.doi.org/10.1177/1179299X17737301
work_keys_str_mv AT mehramrigaya longnoncodingrnasasakeyplayerinhepatocellularcarcinoma
AT chauhanranjit longnoncodingrnasasakeyplayerinhepatocellularcarcinoma