Allopurinol in combination with thiopurine induces mucosal healing and improves clinical and metabolic outcomes in IBD

BACKGROUND: Thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP) are common maintenance medications for inflammatory bowel disease (IBD). Excessive methylation via thiopurine methyltransferase (TPMT) frequently causes therapeutic failure. Allopurinol reduces excessive 6-methyl-mercaptopurine...

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Detalles Bibliográficos
Autores principales: Moreau, Brigitte, Clement, Pierre, Theoret, Yves, Seidman, Ernest G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673019/
https://www.ncbi.nlm.nih.gov/pubmed/29147133
http://dx.doi.org/10.1177/1756283X17733657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673019/
https://www.ncbi.nlm.nih.gov/pubmed/29147133
http://dx.doi.org/10.1177/1756283X17733657

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