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Allopurinol in combination with thiopurine induces mucosal healing and improves clinical and metabolic outcomes in IBD

BACKGROUND: Thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP) are common maintenance medications for inflammatory bowel disease (IBD). Excessive methylation via thiopurine methyltransferase (TPMT) frequently causes therapeutic failure. Allopurinol reduces excessive 6-methyl-mercaptopurine...

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Detalles Bibliográficos
Autores principales:	Moreau, Brigitte, Clement, Pierre, Theoret, Yves, Seidman, Ernest G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673019/ https://www.ncbi.nlm.nih.gov/pubmed/29147133 http://dx.doi.org/10.1177/1756283X17733657

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