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Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder
Following exocytosis, synaptic vesicles (SVs) have to be reformed with the correct complement of proteins in the correct stoichiometry to ensure continued neurotransmission. Synaptophysin is a highly abundant, integral SV protein necessary for the efficient retrieval of the SV SNARE protein, synapto...
Autores principales: | Harper, Callista B., Mancini, Grazia M.S., van Slegtenhorst, Marjon, Cousin, Michael A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673032/ https://www.ncbi.nlm.nih.gov/pubmed/28887151 http://dx.doi.org/10.1016/j.nbd.2017.08.021 |
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