Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

Metastatic cancers produce exosomes that condition pre-metastatic niches in remote microenvironments to favor metastasis. In contrast, here we show that exosomes from poorly metastatic melanoma cells can potently inhibit metastasis to the lung. These “non-metastatic” exosomes stimulate an innate imm...

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Detalles Bibliográficos
Autores principales: Plebanek, Michael P., Angeloni, Nicholas L., Vinokour, Elena, Li, Jia, Henkin, Anna, Martinez-Marin, Dalia, Filleur, Stephanie, Bhowmick, Reshma, Henkin, Jack, Miller, Stephen D., Ifergan, Igal, Lee, Yesung, Osman, Iman, Thaxton, C. Shad, Volpert, Olga V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673063/
https://www.ncbi.nlm.nih.gov/pubmed/29105655
http://dx.doi.org/10.1038/s41467-017-01433-3

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