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Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

Interleukin-15 (IL-15) is essential for the development and maintenance of natural killer (NK) cells. IL-15 activates STAT5 proteins, which can form dimers or tetramers. We previously found that NK cell numbers are decreased in Stat5a−Stat5b tetramer-deficient double knockin (DKI) mice, but the mech...

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Detalles Bibliográficos
Autores principales:	Lin, Jian-Xin, Du, Ning, Li, Peng, Kazemian, Majid, Gebregiorgis, Tesfay, Spolski, Rosanne, Leonard, Warren J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673064/ https://www.ncbi.nlm.nih.gov/pubmed/29105654 http://dx.doi.org/10.1038/s41467-017-01477-5

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