Cargando…

Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score

Oxidative stress has been closely linked to the progressive cell damage associated with emerging non-communicable disease (NCDs). Early detection of these biochemical abnormalities before irreversible cell damage occurs may therefore be useful in identifying disease risk at an individual level. In o...

Descripción completa

Detalles Bibliográficos
Autores principales: Seyedsadjadi, Neda, Berg, Jade, Bilgin, Ayse A., Tung, Chin, Grant, Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673171/
https://www.ncbi.nlm.nih.gov/pubmed/29107974
http://dx.doi.org/10.1371/journal.pone.0187713
_version_ 1783276554443292672
author Seyedsadjadi, Neda
Berg, Jade
Bilgin, Ayse A.
Tung, Chin
Grant, Ross
author_facet Seyedsadjadi, Neda
Berg, Jade
Bilgin, Ayse A.
Tung, Chin
Grant, Ross
author_sort Seyedsadjadi, Neda
collection PubMed
description Oxidative stress has been closely linked to the progressive cell damage associated with emerging non-communicable disease (NCDs). Early detection of these biochemical abnormalities before irreversible cell damage occurs may therefore be useful in identifying disease risk at an individual level. In order to test this hypothesis, this study assessed the relationship between a simple measure of redox status and lifestyle risk factors for NCDs, and the population-based risk score of Framingham. In a cross-sectional study design, 100 apparently healthy middle-aged males (n = 48) and females (n = 52) were asked to complete a comprehensive lifestyle assessment questionnaire, followed by body fat percentage and blood pressure measurements, and blood collection. The ratio of plasma total antioxidant capacity to hydroperoxide (TAC/HPX) was used as an index of redox balance. One-way ANOVA and multiple linear regression analysis were performed to analyse the association between TAC/HPX, lifestyle components and other plasma biomarkers. The TAC/HPX ratio was higher in males compared to females (t(96) = 2.34, P = 0.021). TAC/HPX was also lower in participants with poor sleep quality (t(93) = 2.39, P = 0.019), with high sleep apnoea risk (t(62.2) = 3.32, P = 0.002), with high caffeine (F(2, 93) = 3.97, P = 0.022) and red meat intake (F(2, 93) = 5.55, P = 0.005). These associations were independent of gender. Furthermore, the TAC/HPX ratio decreased with increasing body fat percentage (F(2, 95) = 4.74, P = 0.011) and depression score (t(94) = 2.38, P = 0.019), though these associations were dependent on gender. Importantly, a negative association was observed between TAC/HPX levels and the Framingham risk score in both males (r(45) = -0.39, P = 0.008) and females (r(50) = -0.33, P = 0.019) that was independent of other Framingham risk score components. Findings from this study suggests that a relatively simple measure of redox balance such as the TAC/HPX ratio may be a sensitive indicator of redox stress, and may therefore serve as a useful biomarker for assessing an individual’s specific NCD risk linked to unhealthy lifestyle practices.
format Online
Article
Text
id pubmed-5673171
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-56731712017-11-18 Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score Seyedsadjadi, Neda Berg, Jade Bilgin, Ayse A. Tung, Chin Grant, Ross PLoS One Research Article Oxidative stress has been closely linked to the progressive cell damage associated with emerging non-communicable disease (NCDs). Early detection of these biochemical abnormalities before irreversible cell damage occurs may therefore be useful in identifying disease risk at an individual level. In order to test this hypothesis, this study assessed the relationship between a simple measure of redox status and lifestyle risk factors for NCDs, and the population-based risk score of Framingham. In a cross-sectional study design, 100 apparently healthy middle-aged males (n = 48) and females (n = 52) were asked to complete a comprehensive lifestyle assessment questionnaire, followed by body fat percentage and blood pressure measurements, and blood collection. The ratio of plasma total antioxidant capacity to hydroperoxide (TAC/HPX) was used as an index of redox balance. One-way ANOVA and multiple linear regression analysis were performed to analyse the association between TAC/HPX, lifestyle components and other plasma biomarkers. The TAC/HPX ratio was higher in males compared to females (t(96) = 2.34, P = 0.021). TAC/HPX was also lower in participants with poor sleep quality (t(93) = 2.39, P = 0.019), with high sleep apnoea risk (t(62.2) = 3.32, P = 0.002), with high caffeine (F(2, 93) = 3.97, P = 0.022) and red meat intake (F(2, 93) = 5.55, P = 0.005). These associations were independent of gender. Furthermore, the TAC/HPX ratio decreased with increasing body fat percentage (F(2, 95) = 4.74, P = 0.011) and depression score (t(94) = 2.38, P = 0.019), though these associations were dependent on gender. Importantly, a negative association was observed between TAC/HPX levels and the Framingham risk score in both males (r(45) = -0.39, P = 0.008) and females (r(50) = -0.33, P = 0.019) that was independent of other Framingham risk score components. Findings from this study suggests that a relatively simple measure of redox balance such as the TAC/HPX ratio may be a sensitive indicator of redox stress, and may therefore serve as a useful biomarker for assessing an individual’s specific NCD risk linked to unhealthy lifestyle practices. Public Library of Science 2017-11-06 /pmc/articles/PMC5673171/ /pubmed/29107974 http://dx.doi.org/10.1371/journal.pone.0187713 Text en © 2017 Seyedsadjadi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Seyedsadjadi, Neda
Berg, Jade
Bilgin, Ayse A.
Tung, Chin
Grant, Ross
Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score
title Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score
title_full Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score
title_fullStr Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score
title_full_unstemmed Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score
title_short Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score
title_sort significant relationships between a simple marker of redox balance and lifestyle behaviours; relevance to the framingham risk score
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673171/
https://www.ncbi.nlm.nih.gov/pubmed/29107974
http://dx.doi.org/10.1371/journal.pone.0187713
work_keys_str_mv AT seyedsadjadineda significantrelationshipsbetweenasimplemarkerofredoxbalanceandlifestylebehavioursrelevancetotheframinghamriskscore
AT bergjade significantrelationshipsbetweenasimplemarkerofredoxbalanceandlifestylebehavioursrelevancetotheframinghamriskscore
AT bilginaysea significantrelationshipsbetweenasimplemarkerofredoxbalanceandlifestylebehavioursrelevancetotheframinghamriskscore
AT tungchin significantrelationshipsbetweenasimplemarkerofredoxbalanceandlifestylebehavioursrelevancetotheframinghamriskscore
AT grantross significantrelationshipsbetweenasimplemarkerofredoxbalanceandlifestylebehavioursrelevancetotheframinghamriskscore