Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner

Oxidative stress and mitochondrial dysfunction are important determinants of neurodegeneration in secondary progressive multiple sclerosis (SPMS). We previously showed that febuxostat, a xanthine oxidase inhibitor, ameliorated both relapsing-remitting and secondary progressive experimental autoimmun...

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Detalles Bibliográficos
Autores principales: Honorat, Josephe A., Nakatsuji, Yuji, Shimizu, Mikito, Kinoshita, Makoto, Sumi-Akamaru, Hisae, Sasaki, Tsutomu, Takata, Kazushiro, Koda, Toru, Namba, Akiko, Yamashita, Kazuya, Sanda, Eri, Sakaguchi, Manabu, Kumanogoh, Atsushi, Shirakura, Takashi, Tamura, Mizuho, Sakoda, Saburo, Mochizuki, Hideki, Okuno, Tatsusada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673182/
https://www.ncbi.nlm.nih.gov/pubmed/29107957
http://dx.doi.org/10.1371/journal.pone.0187215

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