Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome

Intracellular accumulation of protein-bound uremic toxins in the setting of cardiorenal syndrome leads to adverse effects on cardiorenal cellular functions, where cardiac hypertrophy and cardiorenal fibrosis are the hallmarks. In this study, we sought to determine if Apoptosis Signal-Regulated Kinas...

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Detalles Bibliográficos
Autores principales: Savira, Feby, Cao, Longxing, Wang, Ian, Yang, Wendi, Huang, Kevin, Hua, Yue, Jucker, Beat M., Willette, Robert N., Huang, Li, Krum, Henry, Li, Zhiliang, Fu, Qiang, Wang, Bing Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673193/
https://www.ncbi.nlm.nih.gov/pubmed/29107962
http://dx.doi.org/10.1371/journal.pone.0187459

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