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The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities

Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both execute similar processes but with different cellular and molecular effects. Given the number of reviews currently available which describe the functional implications of mitochondrial mutations in cancer, this...

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Detalles Bibliográficos
Autores principales: Hertweck, Kate L., Dasgupta, Santanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673620/
https://www.ncbi.nlm.nih.gov/pubmed/29164061
http://dx.doi.org/10.3389/fonc.2017.00262
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author Hertweck, Kate L.
Dasgupta, Santanu
author_facet Hertweck, Kate L.
Dasgupta, Santanu
author_sort Hertweck, Kate L.
collection PubMed
description Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both execute similar processes but with different cellular and molecular effects. Given the number of reviews currently available which describe the functional implications of mitochondrial mutations in cancer, this article focuses on documenting current knowledge in the abundance and distribution of somatic mitochondrial mutations, followed by elucidation of processes which affect the fate of mutations in cancer cells. The conclusion includes an overview of translational implications for mtDNA mutations, as well as recommendations for future research uniting mitochondrial variants and tumorigenesis.
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spelling pubmed-56736202017-11-21 The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities Hertweck, Kate L. Dasgupta, Santanu Front Oncol Oncology Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both execute similar processes but with different cellular and molecular effects. Given the number of reviews currently available which describe the functional implications of mitochondrial mutations in cancer, this article focuses on documenting current knowledge in the abundance and distribution of somatic mitochondrial mutations, followed by elucidation of processes which affect the fate of mutations in cancer cells. The conclusion includes an overview of translational implications for mtDNA mutations, as well as recommendations for future research uniting mitochondrial variants and tumorigenesis. Frontiers Media S.A. 2017-11-02 /pmc/articles/PMC5673620/ /pubmed/29164061 http://dx.doi.org/10.3389/fonc.2017.00262 Text en Copyright © 2017 Hertweck and Dasgupta. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Hertweck, Kate L.
Dasgupta, Santanu
The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities
title The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities
title_full The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities
title_fullStr The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities
title_full_unstemmed The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities
title_short The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities
title_sort landscape of mtdna modifications in cancer: a tale of two cities
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673620/
https://www.ncbi.nlm.nih.gov/pubmed/29164061
http://dx.doi.org/10.3389/fonc.2017.00262
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