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Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid precursor protein (APP) and anti-aging protein Klotho, are likely to be involved in the progression of Alzheimer’s disease (AD). The natural phthalide Ligustilide (LIG) has been demonstrated to protect against ag...

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Detalles Bibliográficos
Autores principales:	Kuang, Xi, Zhou, Hong-Jing, Thorne, Amy H., Chen, Xi-Nan, Li, Lin-Jiao, Du, Jun-Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673635/ https://www.ncbi.nlm.nih.gov/pubmed/29163135 http://dx.doi.org/10.3389/fnagi.2017.00353

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