Downregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster

In Drosophila melanogaster, mesencephalic astrocyte-derived neurotrophic factor (DmMANF) is an evolutionarily conserved ortholog of mammalian MANF and cerebral dopamine neurotrophic factor (CDNF), which have been shown to promote the survival of dopaminergic neurons in the brain. We observed especia...

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Detalles Bibliográficos
Autores principales: Walkowicz, Lucyna, Kijak, Ewelina, Krzeptowski, Wojciech, Górska-Andrzejak, Jolanta, Stratoulias, Vassilis, Woznicka, Olga, Chwastek, Elzbieta, Heino, Tapio I., Pyza, Elzbieta M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673640/
https://www.ncbi.nlm.nih.gov/pubmed/29163014
http://dx.doi.org/10.3389/fnins.2017.00610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673640/
https://www.ncbi.nlm.nih.gov/pubmed/29163014
http://dx.doi.org/10.3389/fnins.2017.00610

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