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Downregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster
In Drosophila melanogaster, mesencephalic astrocyte-derived neurotrophic factor (DmMANF) is an evolutionarily conserved ortholog of mammalian MANF and cerebral dopamine neurotrophic factor (CDNF), which have been shown to promote the survival of dopaminergic neurons in the brain. We observed especia...
Autores principales: | Walkowicz, Lucyna, Kijak, Ewelina, Krzeptowski, Wojciech, Górska-Andrzejak, Jolanta, Stratoulias, Vassilis, Woznicka, Olga, Chwastek, Elzbieta, Heino, Tapio I., Pyza, Elzbieta M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673640/ https://www.ncbi.nlm.nih.gov/pubmed/29163014 http://dx.doi.org/10.3389/fnins.2017.00610 |
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