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A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise
An interaction between obesity, impaired glucose metabolism and sperm function in adults has been observed but it is not known whether exposure to a diet high in fat during the peri-pubertal period can have longstanding programmed effects on reproductive function and gonadal structure. This study ex...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673641/ https://www.ncbi.nlm.nih.gov/pubmed/29163186 http://dx.doi.org/10.3389/fphys.2017.00807 |
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author | Ibáñez, Carlos A. Erthal, Rafaela P. Ogo, Fernanda M. Peres, Maria N. C. Vieira, Henrique R. Conejo, Camila Tófolo, Laize P. Francisco, Flávio A. da Silva Silveira, Sandra Malta, Ananda Pavanello, Audrei Martins, Isabela P. da Silva, Paulo H. O. Jacinto Saavedra, Lucas Paulo Gonçalves, Gessica D. Moreira, Veridiana M. Alves, Vander S. da Silva Franco, Claudinéia C. Previate, Carina Gomes, Rodrigo M. de Oliveira Venci, Renan Dias, Francielle R. S. Armitage, James A. Zambrano, Elena Mathias, Paulo C. F. Fernandes, Glaura S. A. Palma-Rigo, Kesia |
author_facet | Ibáñez, Carlos A. Erthal, Rafaela P. Ogo, Fernanda M. Peres, Maria N. C. Vieira, Henrique R. Conejo, Camila Tófolo, Laize P. Francisco, Flávio A. da Silva Silveira, Sandra Malta, Ananda Pavanello, Audrei Martins, Isabela P. da Silva, Paulo H. O. Jacinto Saavedra, Lucas Paulo Gonçalves, Gessica D. Moreira, Veridiana M. Alves, Vander S. da Silva Franco, Claudinéia C. Previate, Carina Gomes, Rodrigo M. de Oliveira Venci, Renan Dias, Francielle R. S. Armitage, James A. Zambrano, Elena Mathias, Paulo C. F. Fernandes, Glaura S. A. Palma-Rigo, Kesia |
author_sort | Ibáñez, Carlos A. |
collection | PubMed |
description | An interaction between obesity, impaired glucose metabolism and sperm function in adults has been observed but it is not known whether exposure to a diet high in fat during the peri-pubertal period can have longstanding programmed effects on reproductive function and gonadal structure. This study examined metabolic and reproductive function in obese rats programmed by exposure to a high fat (HF) diet during adolescence. The effect of physical training (Ex) in ameliorating this phenotype was also assessed. Thirty-day-old male Wistar rats were fed a HF diet (35% lard w/w) for 30 days then subsequently fed a normal fat diet (NF) for a 40-day recovery period. Control animals were fed a NF diet throughout life. At 70 days of life, animals started a low frequency moderate exercise training that lasted 30 days. Control animals remained sedentary (Se). At 100 days of life, biometric, metabolic and reproductive parameters were evaluated. Animals exposed to HF diet showed greater body weight, glucose intolerance, increased fat tissue deposition, reduced VO(2max) and reduced energy expenditure. Consumption of the HF diet led to an increase in the number of abnormal seminiferous tubule and a reduction in seminiferous epithelium height and seminiferous tubular diameter, which was reversed by moderate exercise. Compared with the NF-Se group, a high fat diet decreased the number of seminiferous tubules in stages VII-VIII and the NF-Ex group showed an increase in stages XI-XIII. HF-Se and NF-Ex animals showed a decreased number of spermatozoa in the cauda epididymis compared with animals from the NF-Se group. Animals exposed to both treatments (HF and Ex) were similar to all the other groups, thus these alterations induced by HF or Ex alone were partially prevented. Physical training reduced fat pad deposition and restored altered reproductive parameters. HF diet consumption during the peri-pubertal period induces long-term changes on metabolism and the reproductive system, but moderate and low frequency physical training is able to recover adipose tissue deposition and reproductive system alterations induced by high fat diet. This study highlights the importance of a balanced diet and continued physical activity during adolescence, with regard to metabolic and reproductive health. |
format | Online Article Text |
id | pubmed-5673641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56736412017-11-21 A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise Ibáñez, Carlos A. Erthal, Rafaela P. Ogo, Fernanda M. Peres, Maria N. C. Vieira, Henrique R. Conejo, Camila Tófolo, Laize P. Francisco, Flávio A. da Silva Silveira, Sandra Malta, Ananda Pavanello, Audrei Martins, Isabela P. da Silva, Paulo H. O. Jacinto Saavedra, Lucas Paulo Gonçalves, Gessica D. Moreira, Veridiana M. Alves, Vander S. da Silva Franco, Claudinéia C. Previate, Carina Gomes, Rodrigo M. de Oliveira Venci, Renan Dias, Francielle R. S. Armitage, James A. Zambrano, Elena Mathias, Paulo C. F. Fernandes, Glaura S. A. Palma-Rigo, Kesia Front Physiol Physiology An interaction between obesity, impaired glucose metabolism and sperm function in adults has been observed but it is not known whether exposure to a diet high in fat during the peri-pubertal period can have longstanding programmed effects on reproductive function and gonadal structure. This study examined metabolic and reproductive function in obese rats programmed by exposure to a high fat (HF) diet during adolescence. The effect of physical training (Ex) in ameliorating this phenotype was also assessed. Thirty-day-old male Wistar rats were fed a HF diet (35% lard w/w) for 30 days then subsequently fed a normal fat diet (NF) for a 40-day recovery period. Control animals were fed a NF diet throughout life. At 70 days of life, animals started a low frequency moderate exercise training that lasted 30 days. Control animals remained sedentary (Se). At 100 days of life, biometric, metabolic and reproductive parameters were evaluated. Animals exposed to HF diet showed greater body weight, glucose intolerance, increased fat tissue deposition, reduced VO(2max) and reduced energy expenditure. Consumption of the HF diet led to an increase in the number of abnormal seminiferous tubule and a reduction in seminiferous epithelium height and seminiferous tubular diameter, which was reversed by moderate exercise. Compared with the NF-Se group, a high fat diet decreased the number of seminiferous tubules in stages VII-VIII and the NF-Ex group showed an increase in stages XI-XIII. HF-Se and NF-Ex animals showed a decreased number of spermatozoa in the cauda epididymis compared with animals from the NF-Se group. Animals exposed to both treatments (HF and Ex) were similar to all the other groups, thus these alterations induced by HF or Ex alone were partially prevented. Physical training reduced fat pad deposition and restored altered reproductive parameters. HF diet consumption during the peri-pubertal period induces long-term changes on metabolism and the reproductive system, but moderate and low frequency physical training is able to recover adipose tissue deposition and reproductive system alterations induced by high fat diet. This study highlights the importance of a balanced diet and continued physical activity during adolescence, with regard to metabolic and reproductive health. Frontiers Media S.A. 2017-11-02 /pmc/articles/PMC5673641/ /pubmed/29163186 http://dx.doi.org/10.3389/fphys.2017.00807 Text en Copyright © 2017 Ibáñez, Erthal, Ogo, Peres, Vieira, Conejo, Tófolo, Francisco, da Silva Silveira, Malta, Pavanello, Martins, da Silva, Jacinto Saavedra, Gonçalves, Moreira, Alves, da Silva Franco, Previate, Gomes, de Oliveira Venci, Dias, Armitage, Zambrano, Mathias, Fernandes and Palma-Rigo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Ibáñez, Carlos A. Erthal, Rafaela P. Ogo, Fernanda M. Peres, Maria N. C. Vieira, Henrique R. Conejo, Camila Tófolo, Laize P. Francisco, Flávio A. da Silva Silveira, Sandra Malta, Ananda Pavanello, Audrei Martins, Isabela P. da Silva, Paulo H. O. Jacinto Saavedra, Lucas Paulo Gonçalves, Gessica D. Moreira, Veridiana M. Alves, Vander S. da Silva Franco, Claudinéia C. Previate, Carina Gomes, Rodrigo M. de Oliveira Venci, Renan Dias, Francielle R. S. Armitage, James A. Zambrano, Elena Mathias, Paulo C. F. Fernandes, Glaura S. A. Palma-Rigo, Kesia A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise |
title | A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise |
title_full | A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise |
title_fullStr | A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise |
title_full_unstemmed | A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise |
title_short | A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise |
title_sort | high fat diet during adolescence in male rats negatively programs reproductive and metabolic function which is partially ameliorated by exercise |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673641/ https://www.ncbi.nlm.nih.gov/pubmed/29163186 http://dx.doi.org/10.3389/fphys.2017.00807 |
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