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Predictive Value of Dynamic Cerebral Autoregulation Assessment in Surgical Management of Patients with High-Grade Carotid Artery Stenosis
Dynamic cerebral autoregulation (DCA) capacity along with the degree of internal carotid artery (ICA) stenosis and characteristics of the plaque can also play an important role in selection of appropriate treatment strategy. This study aims to classify the patients with severe ICA stenosis according...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673646/ https://www.ncbi.nlm.nih.gov/pubmed/29163214 http://dx.doi.org/10.3389/fphys.2017.00872 |
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author | Semenyutin, Vladimir B. Asaturyan, Gregory A. Nikiforova, Anna A. Aliev, Vugar A. Panuntsev, Grigory K. Iblyaminov, Vadim B. Savello, Alexander V. Patzak, Andreas |
author_facet | Semenyutin, Vladimir B. Asaturyan, Gregory A. Nikiforova, Anna A. Aliev, Vugar A. Panuntsev, Grigory K. Iblyaminov, Vadim B. Savello, Alexander V. Patzak, Andreas |
author_sort | Semenyutin, Vladimir B. |
collection | PubMed |
description | Dynamic cerebral autoregulation (DCA) capacity along with the degree of internal carotid artery (ICA) stenosis and characteristics of the plaque can also play an important role in selection of appropriate treatment strategy. This study aims to classify the patients with severe ICA stenosis according to preoperative state of DCA and to assess its dynamics after surgery. Thirty-five patients with severe ICA stenosis having different clinical type of disease underwent reconstructive surgery. DCA was assessed with transfer function analysis (TFA) by calculating phase shift (PS) between Mayer waves of blood flow velocity (BFV) and blood pressure (BP) before and after operation. In 18 cases, regardless of clinical type, preoperative PS on ipsilateral side was within the normal range and did not change considerably after surgery. In other 17 cases preoperative PS was reliably lower both in patients with symptomatic and asymptomatic stenosis. Surgical reconstruction led to restoration of impaired DCA evidenced by significant increase of PS in postoperative period. Our data suggest that regardless clinical type of disease various state of DCA may be present in patients with severe ICA stenosis. This finding can contribute to establishing the optimal treatment strategy, and first of all for asymptomatic patients. Patients with compromised DCA should be considered as ones with higher risk of stroke and first candidates for reconstructive surgery. |
format | Online Article Text |
id | pubmed-5673646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56736462017-11-21 Predictive Value of Dynamic Cerebral Autoregulation Assessment in Surgical Management of Patients with High-Grade Carotid Artery Stenosis Semenyutin, Vladimir B. Asaturyan, Gregory A. Nikiforova, Anna A. Aliev, Vugar A. Panuntsev, Grigory K. Iblyaminov, Vadim B. Savello, Alexander V. Patzak, Andreas Front Physiol Physiology Dynamic cerebral autoregulation (DCA) capacity along with the degree of internal carotid artery (ICA) stenosis and characteristics of the plaque can also play an important role in selection of appropriate treatment strategy. This study aims to classify the patients with severe ICA stenosis according to preoperative state of DCA and to assess its dynamics after surgery. Thirty-five patients with severe ICA stenosis having different clinical type of disease underwent reconstructive surgery. DCA was assessed with transfer function analysis (TFA) by calculating phase shift (PS) between Mayer waves of blood flow velocity (BFV) and blood pressure (BP) before and after operation. In 18 cases, regardless of clinical type, preoperative PS on ipsilateral side was within the normal range and did not change considerably after surgery. In other 17 cases preoperative PS was reliably lower both in patients with symptomatic and asymptomatic stenosis. Surgical reconstruction led to restoration of impaired DCA evidenced by significant increase of PS in postoperative period. Our data suggest that regardless clinical type of disease various state of DCA may be present in patients with severe ICA stenosis. This finding can contribute to establishing the optimal treatment strategy, and first of all for asymptomatic patients. Patients with compromised DCA should be considered as ones with higher risk of stroke and first candidates for reconstructive surgery. Frontiers Media S.A. 2017-11-02 /pmc/articles/PMC5673646/ /pubmed/29163214 http://dx.doi.org/10.3389/fphys.2017.00872 Text en Copyright © 2017 Semenyutin, Asaturyan, Nikiforova, Aliev, Panuntsev, Iblyaminov, Savello and Patzak. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Semenyutin, Vladimir B. Asaturyan, Gregory A. Nikiforova, Anna A. Aliev, Vugar A. Panuntsev, Grigory K. Iblyaminov, Vadim B. Savello, Alexander V. Patzak, Andreas Predictive Value of Dynamic Cerebral Autoregulation Assessment in Surgical Management of Patients with High-Grade Carotid Artery Stenosis |
title | Predictive Value of Dynamic Cerebral Autoregulation Assessment in Surgical Management of Patients with High-Grade Carotid Artery Stenosis |
title_full | Predictive Value of Dynamic Cerebral Autoregulation Assessment in Surgical Management of Patients with High-Grade Carotid Artery Stenosis |
title_fullStr | Predictive Value of Dynamic Cerebral Autoregulation Assessment in Surgical Management of Patients with High-Grade Carotid Artery Stenosis |
title_full_unstemmed | Predictive Value of Dynamic Cerebral Autoregulation Assessment in Surgical Management of Patients with High-Grade Carotid Artery Stenosis |
title_short | Predictive Value of Dynamic Cerebral Autoregulation Assessment in Surgical Management of Patients with High-Grade Carotid Artery Stenosis |
title_sort | predictive value of dynamic cerebral autoregulation assessment in surgical management of patients with high-grade carotid artery stenosis |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673646/ https://www.ncbi.nlm.nih.gov/pubmed/29163214 http://dx.doi.org/10.3389/fphys.2017.00872 |
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