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Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes

Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribut...

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Detalles Bibliográficos
Autores principales:	Björk, Susann, Ojala, Elina A., Nordström, Tommy, Ahola, Antti, Liljeström, Mikko, Hyttinen, Jari, Kankuri, Esko, Mervaala, Eero
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673656/ https://www.ncbi.nlm.nih.gov/pubmed/29163220 http://dx.doi.org/10.3389/fphys.2017.00884

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