Cargando…

In-Vitro Transcription analysis of NS5A from HCV-3a circulating in Pakistani patients with chronic hepatitis C and their differential response to antiviral therapy

OBJECTIVE: Mutations in HCV nonstructural protein 5A (NS5A) play a vital role in virus resistance. The aim of this study was to develop a correlation between NS5A mutations (genotype 3a) and virological response towards interferon alpha (IFN-α) plus ribavirin therapy. METHODS: In this study, which w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhatti, Shameem, Manzoor, Sobia, Parvaiz, Fahed, Ashraf, Javed, Javed, Farakh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Professional Medical Publications 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673740/ https://www.ncbi.nlm.nih.gov/pubmed/29142571 http://dx.doi.org/10.12669/pjms.335.12973

Ejemplares similares

Hepatitis C Virus Infection: Molecular Pathways to Insulin resistance
por: Parvaiz, Fahed, et al.
Publicado: (2011)

Molecular epidemiology and clinical features of Hepatitis C Virus (HCV) in epidemic areas of Interior Sindh, Pakistan
por: Bhatti, Shameem, et al.
Publicado: (2016)

Docking Studies of Pakistani HCV NS3 Helicase: A Possible Antiviral Drug Target
por: Fatima, Kaneez, et al.
Publicado: (2014)

Pre-existing resistance associated polymorphisms to NS3 protease inhibitors in treatment naïve HCV positive Pakistani patients
por: Khan, Hafeez Ullah, et al.
Publicado: (2020)

Response to combination therapy of HCV 3a infected Pakistani patients and the role of NS5A protein
por: Ali, Ijaz, et al.
Publicado: (2011)

Antioxidants and Calcium Modulators Preclude in Vitro Hepatitis B Virus–Induced Mitochondrial Damage
por: Jabeen, Kehkshan, et al.
Publicado: (2023)

Performance of NS3, NS5a AND NS5b Hepatitis C Virus (HCV) Antiviral Resistance Sequencing Assays
por: Nutt, Jamie, et al.
Publicado: (2017)

Phylogenetic analysis of torque teno virus genome from Pakistani isolate and incidence of co-infection among HBV/HCV infected patients
por: Hussain, Tabinda, et al.
Publicado: (2012)

The Future of HCV Therapy: NS4B as an Antiviral Target
por: Dvory-Sobol, Hadas, et al.
Publicado: (2010)

Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a
por: Fatima, Kaneez, et al.
Publicado: (2014)

Direct Binding of Ledipasvir to HCV NS5A: Mechanism of Resistance to an HCV Antiviral Agent
por: Kwon, Hyock Joo, et al.
Publicado: (2015)

Identification of ionotrophic purinergic receptors in Huh-7 cells and their response towards structural proteins of HCV genotype 3a
por: Manzoor, Sobia, et al.
Publicado: (2011)

Serum MicroRNAs as Predictors for HCV Progression and Response to Treatment in Pakistani Patients
por: Manzoor, Sadia, et al.
Publicado: (2023)

Role of viral and host factors in interferon based therapy of hepatitis C virus infection
por: Imran, Muhammad, et al.
Publicado: (2013)

Emergence and Persistence of Resistance-Associated Substitutions in HCV GT3 Patients Failing Direct-Acting Antivirals
por: Mushtaq, Saima, et al.
Publicado: (2022)

HCV Envelope protein 2 sequence comparison of Pakistani isolate and In-silico prediction of conserved epitopes for vaccine development
por: Idrees, Sobia, et al.
Publicado: (2013)

Phylogenetic and 2D/3D Analysis of HCV 1a NS4A Gene/Protein in Pakistani Isolates
por: Hussain, Abrar, et al.
Publicado: (2015)

P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis
por: Manzoor, Sobia, et al.
Publicado: (2022)

Nucleotide identity and variability among different Pakistani hepatitis C virus isolates
por: Idrees, Muhammad, et al.
Publicado: (2009)

Predicting anthropometric and metabolic traits with a genetic risk score for obesity in a sample of Pakistanis
por: Rana, Sobia, et al.
Publicado: (2021)

The Phylogeographic and Spatiotemporal Spread of HCV in Pakistani Population
por: Ghori, Noor-Ul-Huda, et al.
Publicado: (2016)

Occurrence of genetic modifications in core, 5′UTR and NS5b of HCV associated with viral response to treatment
por: Kanwal, Sobia, et al.
Publicado: (2014)

Computer aided screening of Accacia nilotica phytochemicals against HCV NS3/4a
por: Khan, Mahim, et al.
Publicado: (2013)

In-vitro antiviral activity of Solanum nigrum against Hepatitis C Virus
por: Javed, Tariq, et al.
Publicado: (2011)

Molecular screening of phytochemicals from Amelanchier Alnifolia against HCV NS3 protease/helicase using computational docking techniques
por: Khan, Mahim, et al.
Publicado: (2013)

Development of novel antiviral nanofinishes for bioactive textiles
por: Afzal, Farheen, et al.
Publicado: (2022)

Antiviral drugs against hepatitis C virus
por: Rehman, Sidra, et al.
Publicado: (2011)

Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection
por: Sillanpää, Maarit, et al.
Publicado: (2009)

Serology based disease status of Pakistani population infected with Hepatitis B virus
por: Alam, Muhammad Masroor, et al.
Publicado: (2007)

Characterization of the Gastrointestinal and Reproductive Tract Microbiota in Fertile and Infertile Pakistani Couples
por: Manzoor, Ammara, et al.
Publicado: (2021)

Identification of NS2 determinants stimulating intrinsic HCV NS2 protease activity
por: Isken, Olaf, et al.
Publicado: (2022)

Characterization of Naturally Occurring NS5A and NS5B Polymorphisms in Patients Infected with HCV Genotype 3a Treated with Direct-Acting Antiviral Agents
por: Bartolini, Barbara, et al.
Publicado: (2017)

Gestational diabetes mellitus is rare in primigravida Pakistani women
por: Jawa, Ali, et al.
Publicado: (2011)

In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir
por: Ng, Teresa I., et al.
Publicado: (2017)

Prevalence of hepatitis C virus (HCV) variants resistant to NS5A inhibitors in naïve patients infected with HCV genotype 1 in Tunisia
por: Aissa Larousse, Jameleddine, et al.
Publicado: (2015)

Cloning and Expression of NS3 Gene of Pakistani Isolate Type 2 Dengue Virus
por: Yasmin, Farkhanda, et al.
Publicado: (2018)

Hepatic steatosis in HCV-infected persons in the direct-acting antiviral era
por: Stevenson, Heather L., et al.
Publicado: (2016)

Implications of hcv natural genetic diversity on HCV NS5B inhibitor NM283
por: Demetriou, Victoria L, et al.
Publicado: (2010)

Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease
por: El-Araby, Moustafa E., et al.
Publicado: (2020)

Association of Interleukin-6 Gene Promoter Polymorphism with Coronary Artery Disease in Pakistani Families
por: Satti, Humayoon Shafiq, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_rpmn6h0q93gq29nk1tcgt5865s