Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation

Prolonged use of mechanical ventilation (MV) leads to atrophy and dysfunction of the major inspiratory muscle, the diaphragm, contributing to ventilator dependence. Numerous studies have shown that proteolysis and oxidative stress are among the major effectors of ventilator-induced diaphragm muscle...

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Detalles Bibliográficos
Autores principales: Tang, Huibin, L. Kennedy, Catherine, Lee, Myung, Gao, Yang, Xia, Hui, Olguin, Francesca, Fraga, Danielle A., Ayers, Kelsey, Choi, Sehoon, Kim, Michael, Tehrani, Amir, Sowb, Yasser A., Rando, Thomas A., Shrager, Joseph B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673963/
https://www.ncbi.nlm.nih.gov/pubmed/29109401
http://dx.doi.org/10.1038/s41598-017-11978-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673963/
https://www.ncbi.nlm.nih.gov/pubmed/29109401
http://dx.doi.org/10.1038/s41598-017-11978-4

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