Cargando…

Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A

Rare ent-abietane-rosane diterpenoid heterodimers, Bisebracteolasins A and B (1 and 2, respectively), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures and absolute configurations were elucidated from spectroscopic data and X-ray diffraction analysis. Compounds 1 and 2...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Wen-Juan, Ding, Xiao, Wang, Zhe, Yang, Bi-Juan, Li, Xiao-Nian, Zhang, Yu, Chen, Duo-Zhi, Li, Shun-Lin, Chen, Quan, Di, Ying-Tong, Aisa, Haji Akber, Hao, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674023/
https://www.ncbi.nlm.nih.gov/pubmed/29109538
http://dx.doi.org/10.1038/s41598-017-14637-w
_version_ 1783276689621516288
author Yuan, Wen-Juan
Ding, Xiao
Wang, Zhe
Yang, Bi-Juan
Li, Xiao-Nian
Zhang, Yu
Chen, Duo-Zhi
Li, Shun-Lin
Chen, Quan
Di, Ying-Tong
Aisa, Haji Akber
Hao, Xiao-Jiang
author_facet Yuan, Wen-Juan
Ding, Xiao
Wang, Zhe
Yang, Bi-Juan
Li, Xiao-Nian
Zhang, Yu
Chen, Duo-Zhi
Li, Shun-Lin
Chen, Quan
Di, Ying-Tong
Aisa, Haji Akber
Hao, Xiao-Jiang
author_sort Yuan, Wen-Juan
collection PubMed
description Rare ent-abietane-rosane diterpenoid heterodimers, Bisebracteolasins A and B (1 and 2, respectively), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures and absolute configurations were elucidated from spectroscopic data and X-ray diffraction analysis. Compounds 1 and 2 exhibited moderate cytotoxic effects against five cancer cell lines. Compound 1 showed more effective antiproliferative activities against human tumour cells, HL-60 and SMMC-7721, with IC(50) values of 2.61 and 4.08 μM, respectively, than 2. Both compounds 1 and 2 inhibit the colorectal cancer stem cell line P6C with IC(50) values of 16.48 and 34.76 μM, respectively. Moreover, preliminary biological tests showed compound 1 exhibited inhibitory activity towards tumoursphere formation and migration of the P6C cell line. Overall, we identified two novel diterpenoid heterodimers, and Bisebracteolasin A exhibits therapeutic potential in impeding tumour growth and metastatic ability of cancer stem cells.
format Online
Article
Text
id pubmed-5674023
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-56740232017-11-15 Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A Yuan, Wen-Juan Ding, Xiao Wang, Zhe Yang, Bi-Juan Li, Xiao-Nian Zhang, Yu Chen, Duo-Zhi Li, Shun-Lin Chen, Quan Di, Ying-Tong Aisa, Haji Akber Hao, Xiao-Jiang Sci Rep Article Rare ent-abietane-rosane diterpenoid heterodimers, Bisebracteolasins A and B (1 and 2, respectively), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures and absolute configurations were elucidated from spectroscopic data and X-ray diffraction analysis. Compounds 1 and 2 exhibited moderate cytotoxic effects against five cancer cell lines. Compound 1 showed more effective antiproliferative activities against human tumour cells, HL-60 and SMMC-7721, with IC(50) values of 2.61 and 4.08 μM, respectively, than 2. Both compounds 1 and 2 inhibit the colorectal cancer stem cell line P6C with IC(50) values of 16.48 and 34.76 μM, respectively. Moreover, preliminary biological tests showed compound 1 exhibited inhibitory activity towards tumoursphere formation and migration of the P6C cell line. Overall, we identified two novel diterpenoid heterodimers, and Bisebracteolasin A exhibits therapeutic potential in impeding tumour growth and metastatic ability of cancer stem cells. Nature Publishing Group UK 2017-11-06 /pmc/articles/PMC5674023/ /pubmed/29109538 http://dx.doi.org/10.1038/s41598-017-14637-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yuan, Wen-Juan
Ding, Xiao
Wang, Zhe
Yang, Bi-Juan
Li, Xiao-Nian
Zhang, Yu
Chen, Duo-Zhi
Li, Shun-Lin
Chen, Quan
Di, Ying-Tong
Aisa, Haji Akber
Hao, Xiao-Jiang
Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
title Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
title_full Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
title_fullStr Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
title_full_unstemmed Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
title_short Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
title_sort two novel diterpenoid heterodimers, bisebracteolasins a and b, from euphorbia ebracteolata hayata, and the cancer chemotherapeutic potential of bisebracteolasin a
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674023/
https://www.ncbi.nlm.nih.gov/pubmed/29109538
http://dx.doi.org/10.1038/s41598-017-14637-w
work_keys_str_mv AT yuanwenjuan twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT dingxiao twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT wangzhe twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT yangbijuan twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT lixiaonian twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT zhangyu twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT chenduozhi twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT lishunlin twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT chenquan twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT diyingtong twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT aisahajiakber twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina
AT haoxiaojiang twonovelditerpenoidheterodimersbisebracteolasinsaandbfromeuphorbiaebracteolatahayataandthecancerchemotherapeuticpotentialofbisebracteolasina